{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:45:17Z","timestamp":1786157117712,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2002567"],"award-info":[{"award-number":["APP2002567"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["102062"],"award-info":[{"award-number":["102062"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Venoarterial extracorporeal membrane oxygenation (ECMO) provides mechanical support for critically ill patients with cardiogenic shock. Typically, the size of the arterial return cannula is chosen to maximize flow. However, smaller arterial cannulae may reduce cannula\u2010related complications and be easier to insert. This in vitro study quantified the hemodynamic effect of different arterial return cannula sizes in a simulated acute heart failure patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline support levels were simulated with a 17 Fr arterial cannula in an ECMO circuit attached to a cardiovascular simulator with targeted partial (2.0\u00a0L\/min ECMO flow, 60\u201365\u00a0mm\u00a0Hg mean aortic pressure\u2014MAP) and targeted full ECMO support (3.5\u00a0L\/min ECMO flow and 70\u201375\u00a0mm\u00a0Hg MAP). Return cannula size was varied (13\u201321 Fr), and hemodynamics were recorded while keeping ECMO pump speed constant and adjusting pump speed to restore desired support levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Minimal differences in hemodynamics were found between cannula sizes in partial support mode. A maximum pump speed change of +600\u00a0rpm was required to reach the support target, and arterial cannula inlet pressure varied from 79 (21 Fr) to 224\u00a0mm\u00a0Hg (13 Fr). The 15 Fr arterial cannula could provide the target full ECMO support at the targeted hemodynamics; however, the 13 Fr cannula could not due to the high resistance associated with the small diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 15 Fr arterial return cannula provided targeted partial and full ECMO support to a simulated acute heart failure patient. Balancing reduced cannula size and ECMO support level may improve patient outcomes by reducing cannula\u2010related adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14179","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T05:10:54Z","timestamp":1642655454000},"page":"1068-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hemodynamics of small arterial return cannulae for venoarterial extracorporeal membrane oxygenation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-750X","authenticated-orcid":false,"given":"Andrew F.","family":"Stephens","sequence":"first","affiliation":[{"name":"Cardio\u2010Respiratory Engineering and Technology Laboratory Baker Heart and Diabetes Institute  Melbourne Victoria Australia"},{"name":"Department of Mechanical and Aerospace Engineering Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-7009","authenticated-orcid":false,"given":"Avishka","family":"Wickramarachchi","sequence":"additional","affiliation":[{"name":"Cardio\u2010Respiratory Engineering and Technology Laboratory Baker Heart and Diabetes Institute  Melbourne Victoria Australia"},{"name":"Department of Mechanical and Aerospace Engineering Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-9678","authenticated-orcid":false,"given":"Aidan J. C.","family":"Burrell","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Austin Hospital  Melbourne Victoria Australia"},{"name":"Department of Critical Care The University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre Monash University, School of Public Health and Preventive Medicine  Melbourne Victoria Australia"},{"name":"Department of Intensive Care Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaishankar","family":"Raman","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery University of Melbourne, Austin, &amp; St Vincent\u2019s Hospitals  Melbourne Victoria 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