{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:42:27Z","timestamp":1786160547004,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical predictors for successful weaning of patients from Impella heart pump have not been clarified. We aimed to elucidate the relationship between pulmonary artery catheter (PAC) parameters at the time of Impella weaning and subsequent outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled consecutive patients who had received Impella for cardiogenic shock. PAC data were collected immediately before Impella weaning. Patients were classified as non\u2010survivors if they died or required any mechanical circulatory support reintroduction within 30\u00a0days of weaning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 81 patients enrolled, 61 underwent Impella weaning. Of these, 16 were non\u2010survivors. Predictive indicators of non\u2010survival were high pulmonary artery wedge pressure (PAWP; hazard ratio [HR] per 5\u00a0mm\u00a0Hg 1.97, 95% CI 1.35\u20132.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), high mean pulmonary artery pressure (MPAP; HR per 5\u00a0mm\u00a0Hg 1.90, 1.38\u20132.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and low cardiac power output (CPO; HR per 0.1 Watts 0.71, 0.52\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006). Cutoff values of PAWP 20\u00a0mm\u00a0Hg, MPAP 22\u00a0mm\u00a0Hg, and CPO 0.59 Watts showed strong associations with 30\u2010day non\u2010survival risk (low risk 8% in patients with low PAWP and high CPO or 4% in patients with low MPAP and high CPO; high risk 100% in patients with high PAWP and low CPO or 82% in patients with high MPAP and low CPO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PAWP or MPAP higher than the cutoff with CPO below the cutoff at Impella weaning were associated with worse outcomes. We proposed a risk classification model for successful Impella weaning using PAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14197","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T23:03:37Z","timestamp":1644275017000},"page":"1358-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hemodynamic assessment and risk classification for successful weaning of Impella in patients with cardiogenic shock"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-5010","authenticated-orcid":false,"given":"Yuki","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular 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