{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:45:14Z","timestamp":1786157114088,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with severe coronavirus disease\u201019 (COVID\u201019)\u2010associated acute respiratory distress on venovenous extracorporeal lung support (V\u2010V ECLS) showed a high incidence of vascular as well as ECLS\u2010related thrombotic complications. The latter may influence the outcome of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective monocentric study on prospectively collected data of technical complications including 69 adult COVID\u201019 patients on V\u2010V ECLS (ECLS Registry, March 2020 until April 2021) without and with system exchanges. Alterations in ECLS\u2010specific data, hemolysis, coagulation, and hemostasis parameters were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Every second COVID\u201019 patient on V\u2010V ECLS developed technical complications. Optimized ECLS management at our ECLS center reduced cases of acute clot formation (pump head thrombosis, acute oxygenator thrombosis) (17%), and allowed early identification of progressive clotting processes (worsened gas transfer, coagulation disorder) (14%, 54%) with a significant overhang of hyperfibrinolysis (37%). Although COVID\u201019 disease and technical complications caused the prolonged length of stay at the intensive care unit and ECLS support times, the proportion of successful weaning and survival rates were comparable with patients without system exchange.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The survival of ECLS patients with COVID\u201019 was independent of the requirement for system exchange due to technical\u2010induced coagulation disorders. Close monitoring for circuit clotting is mandatory in COVID\u201019 patients and is one prerequisite for successful organ support in these difficult patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14218","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T09:19:25Z","timestamp":1645521565000},"page":"1669-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Coagulation abnormalities in patients with COVID\u201019 on venovenous ECLS increased risk for technical complications and support times but had no impact on survival"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-4094","authenticated-orcid":false,"given":"Karla","family":"Lehle","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital Regensburg  Regensburg 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