{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:45:15Z","timestamp":1786157115255,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyponatremia is associated with adverse outcomes in heart failure and after cardiac surgery. We hypothesized that hyponatremia is associated with poorer short\u2010term and longer term survival in patients after continuous\u2010flow left ventricular assist device (CF\u2010LVAD) placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed a single\u2010center database of patients who received a CF\u2010LVAD during 2012\u20132017. Sodium (Na) values obtained within 14\u2009days before CF\u2010LVAD insertion were averaged; patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0332) were divided into hyponatremia (mean Na &lt;135\u2009mEq\/L;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0160; 48.2%) and normonatremia groups (mean Na 135\u2013145\u2009mEq\/L;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0172; 51.8%). Patients requiring preoperative dialysis or pump exchange were excluded. We compared outcomes between preoperative hyponatremia and normonatremia groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two groups\u2019 baseline characteristics were similar, although hyponatremia patients more often had preoperative mechanical circulatory support (44.4% vs. 31.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). Although hyponatremic and normonatremic patients did not differ in 30\u2010day mortality (7.5% vs. 6.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.7), preoperative hyponatremia was associated with greater 5\u2010year mortality (61% vs. 44%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). On binary logistic regression analysis, the strongest independent predictors of late mortality were hyponatremia (odds ratio [OR] 1.88, 95% CI [1.07\u20133.31],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), older age (OR 1.03, 95% CI [1.01\u20131.05],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01), and elevated mean right atrial pressure\/pulmonary capillary wedge pressure ratio (OR 4.69, 95% CI [1.76\u201312.47],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hyponatremia was not associated with greater early mortality but was associated with poorer late survival. The optimal timing of LVAD implantation in relation to hyponatremia, and whether correcting hyponatremia perioperatively improves long\u2010term survival, should be investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14280","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T03:34:51Z","timestamp":1651894491000},"page":"1923-1931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative hyponatremia and survival after left ventricular assist device implantation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0611-1030","authenticated-orcid":false,"given":"Harveen K.","family":"Lamba","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang M.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Vincent","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-1891","authenticated-orcid":false,"given":"Andrew B.","family":"Civitello","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Cardiology Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-4985","authenticated-orcid":false,"given":"Ajith","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Cardiology Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-2442","authenticated-orcid":false,"given":"Anju","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Center for Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-1011","authenticated-orcid":false,"given":"Mourad H.","family":"Senussi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Loor","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Cardiovascular Surgery Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis E.","family":"Shafii","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Cardiovascular Surgery Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth K.","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Cardiovascular Surgery Texas Heart Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-8826","authenticated-orcid":false,"given":"Subhasis","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Texas Heart Institute  Houston Texas USA"},{"name":"Division of General Surgery, Michael E. DeBakey Department of Surgery Baylor College Medicine  Houston Texas USA"},{"name":"Division of Cardiothoracic Surgery, Michael E. 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