{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:37:36Z","timestamp":1789576656785,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cardiogenic shock (CS) often occurs in patients suffering from rapidly progressing end\u2010stage heart failure or acute myocardial infarction. Mechanical circulatory support may be used for patients who do not respond to medication or revascularization to stabilize hemodynamics. Extracorporeal ventricular assist device (Extra\u2010VAD) has been reported to be successful for patients with cardiogenic shock. This study aimed to evaluate the 30\u2010day in\u2010vivo performance and safety of a newly developed Extra\u2010VAD with maglev centrifugal pump technology, MoyoAssist\u00ae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The study was conducted with 6 healthy ovine models, weighing 43.2\u2009~\u200959.6 kg. Cannulation was performed with a 34 Fr venous cannula surgically connected to the left arterial appendage and a 24 Fr arterial cannula inserted into descending aorta. The pump flow rate was maintained at 2\u2009~\u20093\u00a0L\/min to provide sufficient cardiac support without suction. Activated clotting time was maintained within the range of 150\u2009~\u2009250\u2009s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No device\u2010related adverse events occurred throughout the study. Plasma\u2010free hemoglobin results were within the acceptable range of ventricular assist device therapy (&lt;40\u2009mg\/dl). MGS01 had an anticoagulation management related bleeding event and was terminated on day 29. All other sheep's biochemical test results were stable. The autopsy showed no embolism or thrombus formation and no end\u2010organ damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that the MoyoAssist\u00ae Extra\u2010VAD is able to provide cardiac support effectively and safely and may provide a new alternative choice for patients with CS in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14317","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T04:03:58Z","timestamp":1652760238000},"page":"2171-2178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["30\u2010day in vivo study of a fully maglev extracorporeal ventricular assist device"],"prefix":"10.1111","volume":"46","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Union Hospital, Tongji Medical College of Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-323X","authenticated-orcid":false,"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Artificial Organ Technology Lab School of Mechanical and Electrical Engineering, Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-2740","authenticated-orcid":false,"given":"Po\u2010Lin","family":"Hsu","sequence":"additional","affiliation":[{"name":"Artificial Organ Technology Lab School of Mechanical and Electrical Engineering, Soochow University  Suzhou China"},{"name":"magAssist, Inc.  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Wuxi Mingci Cardiovascular Hospital  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianguo","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Union Hospital, Tongji Medical College of Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.11.05"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31047-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.03.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.10.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.05.031"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000225"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001039"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu029"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000117"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-017-0582-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.01.021"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:41:43Z","timestamp":1786156903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/aor.14317"],"URL":"https:\/\/doi.org\/10.1111\/aor.14317","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"assertion":[{"value":"2021-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}