{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:02:24Z","timestamp":1778270544370,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FP027\u20102015A"],"award-info":[{"award-number":["FP027\u20102015A"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["PG349\u20102016A"],"award-info":[{"award-number":["PG349\u20102016A"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Repetitive electrically\u2010evoked muscle contractions lead to the early onset of muscle fatigue. This study assessed the relationship between muscle mechanomyography (%RMS\u2010MMG) and tissue oxygen saturation (%TSI) in extensor carpi radialis (ECR) during electrically\u2010evoked fatiguing exercise in individuals with tetraplegia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin\u2010surface mechanomyography (MMG) and near\u2010infrared spectroscopy (NIRS) sensors were placed on the ECR of seven individuals with tetraplegia. All participants performed repetitive electrically\u2010evoked wrist extension to fatigue while their muscle MMG and NIRS responses were monitored against their power output (PO). Findings: One out of seven participants showed no changes in %TSI throughout the repeated wrist FES\u2010evoked contraction. The other six participants' %TSI was positively correlated with %PO before fatigue onset. At 50%PO<jats:sub>peak<\/jats:sub>, %TSI was negatively correlated (0.489) significantly with declining %PO as the ability of the muscle to take up oxygen became limited. The %RMS\u2010MMG behaved analogously during pre and post\u2010fatigue against declining %PO, whereby both displayed positive correlations of 0.443 and 0.214, respectively, (%RMS\u2010MMG decreased) throughout the exercise session. Regression analysis revealed that %TSI was proportional to pre\u2010fatigue and inversely proportional to %RMS\u2010MMG during post\u2010fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The significant changes in muscle mechanomyography and tissue oxygenation correlations after 50%PO<jats:sub>peak<\/jats:sub> implied that the muscle contraction mechanical\u2010and\u2010physiological behavior association had been altered following FES\u2010evoked fatigue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14329","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T14:28:53Z","timestamp":1654439333000},"page":"1998-2008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanomyography and tissue oxygen saturation during electrically\u2010evoked wrist extensor fatigue in people with tetraplegia"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-9126","authenticated-orcid":false,"given":"Nurul Salwani","family":"Mohamad Saadon","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering University of Malaya  Kuala Lumpur Malaysia"},{"name":"Clinical Investigation Centre (CIC) University Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-2813","authenticated-orcid":false,"given":"Nur Azah","family":"Hamzaid","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5775-428X","authenticated-orcid":false,"given":"Nazirah","family":"Hasnan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Afiq","family":"Dzulkifli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-7678","authenticated-orcid":false,"given":"Mira","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-3757","authenticated-orcid":false,"given":"Glen M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Discipline of Exercise and Sport Sciences Sydney School of Health Sciences Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1310\/sci2104\u2010294"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00094.2011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00340.2001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101379"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(97)90425-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90011-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050609"},{"key":"e_1_2_10_10_1","first-page":"45","article-title":"Effects of interphase interval during neuromuscular electrical stimulation of the wrist extensors with maximally tolerated current intensity","volume":"11","author":"Elboim\u2010Gabyzon M","year":"2020","journal-title":"Artif Organs"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/7333.928576"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101594.1999.06362.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101594.2005.29075.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101644"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012922"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-02913-9_133"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.139477"},{"issue":"10","key":"e_1_2_10_18_1","first-page":"5","article-title":"Human muscle fatigue: the significance of muscle fibre type variability studied using a micro\u2010dissection approach","volume":"57","author":"Sargeant AJ","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/68.1.51"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2004.03.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100838.2002.20106.x"},{"key":"e_1_2_10_22_1","first-page":"4","volume-title":"12th Annual Conference of the International FES Society","author":"Hettinga D","year":"2007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/6\/064001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/s110403545"},{"key":"e_1_2_10_25_1","article-title":"Electrically evoked wrist extensor muscle fatigue throughout repetitive motion as measured by mechanomyography and near\u2010infrared spectroscopy","author":"Mohamad Saadon NS","year":"2018","journal-title":"Biomed Eng"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6447-1_13"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1179\/204577211X13207446293695"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1654-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.12.127002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12052"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2657-0"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20000247"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0924-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095582"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7756-4_48"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00921.2005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00166.2018"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1967.22.1.61"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-6411(98)00035-2"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0962-8"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12541-016-0059-z"},{"issue":"2","key":"e_1_2_10_42_1","first-page":"37","article-title":"Surface mechanomyographic responses to muscle fatigue","volume":"661","author":"Beck TW","year":"2010","journal-title":"Transworld Res Netw"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150308"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICSGRC.2014.6908719"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2128-4"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010010\u20101502\u2010y"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/jes.0b013e3180a0321b"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:30:56Z","timestamp":1692689456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/aor.14329"],"URL":"https:\/\/doi.org\/10.1111\/aor.14329","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"assertion":[{"value":"2021-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}