{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:45:15Z","timestamp":1786157115122,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extracorporeal life support (ECLS) is a salvage treatment for acute circulatory failure. Our high\u2010volume tertiary centre performs more than 100 implants annually and provides ECLS\u2010transports. With this study, we aimed to analyze the incidence and risk factors of limb ischemia depending on the vascular access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 1, 2007, and December 31, 2018, 937 patients received an ECLS. Preoperative, intraoperative, in\u2010hospital and up to 5\u2009years follow\u2010up data were collected. Outcome measures were limb ischemia and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 402 femoro\u2010femoral veno\u2010arterial ECLS patients were identified. Mean age was 56\u2009\u00b1\u200916.7\u2009years, 26.9% were female, 7.9% had a history of peripheral vascular disease. Cannulation was performed percutaneously in 82.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0330), surgically in 5.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a023) and combined in 12.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049). Mortality was not significantly different between the groups (51.1% percutaneous, 43.5% surgical, 44.9% combined [\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.89]). There was no significant difference in limb ischemia either, but a trend toward an increased frequency in the percutaneous group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0501). No amputation was necessary. Limb ischemia slightly increased in\u2010hospital mortality (54.6%) but did not affect long\u2010term survival beyond 30\u2009days. Univariate analysis adjusted for cannulation methods revealed younger age and female gender as risk factors of limb ischemia and younger age for limb ischemia after percutaneous cannulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study shows that percutaneous, surgical, and combined vascular access techniques for ECLS implantation are associated with comparable and low incidence of limb ischemia which slightly increases in\u2010hospital mortality. Special precaution has to be taken in young and female patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14344","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:22:25Z","timestamp":1655709745000},"page":"2284-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Acute limb ischemia after femoro\u2010femoral extracorporeal life support implantation: A comparison of surgical, percutaneous, or combined vascular access in 402 patients"],"prefix":"10.1111","volume":"46","author":[{"given":"Markus J.","family":"Wilhelm","sequence":"first","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devdas Thomas","family":"Inderbitzin","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Malorgio","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Aser","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"G\u00fclmez","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Aigner","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Robert","family":"Vogt","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-0441","authenticated-orcid":false,"given":"Diana","family":"Reser","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Hirslanden Heart Clinic  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv194"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2014.09.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.01.037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.095"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-1015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.10.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.10.043"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"682","article-title":"Extracorporeal membranous oxygenation support for acute fulminant myocarditis: analysis of a single center's 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