{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:01:44Z","timestamp":1784354504585,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The hospital mortality of patients suffering from pulmonary failure requiring venovenous extracorporeal membrane oxygenation (V\u2010V ECMO) or extracorporeal carbon dioxide removal (ECCO<jats:sub>2<\/jats:sub>R) is high. It is unclear whether outcome correlates with a hospital's annual procedural volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on all V\u2010V ECMO and ECCO<jats:sub>2<\/jats:sub>R cases treated from 2007 to 2019 were retrieved from the German Institute for Medical Documentation and Information. Comorbidities and outcomes were assessed by DRG, OPS, and ICD codes. The study population was divided into 5 groups depending on annual hospital V\u2010V ECMO and ECCO<jats:sub>2<\/jats:sub>R volumes (&lt;10 cases; 10\u201319 cases; 20\u201329 cases; 30\u201349 cases; \u226550 cases). Primary outcome was hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25\u2009096\u2009V\u2010V ECMO and 3607 ECCO<jats:sub>2<\/jats:sub>R cases were analyzed. V\u2010V ECMO hospitals increased from 89 in 2007 to 214 in 2019. Hospitals handling &lt;10 cases annually increased especially (64 in 2007 to 149 in 2019). V\u2010V ECMO cases rose from 807 in 2007 to 2597 in 2019. Over 50% of cases were treated in hospitals handling \u226530 cases annually. Hospital mortality was independent of the annual hospital procedural volume (55.3%; 61.3%; 59.8%; 60.2%; 56.3%, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.287). We detected no differences when comparing hospitals handling &lt;30 cases to those with \u226530 annually (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.659). The numbers of ECCO<jats:sub>2<\/jats:sub>R hospitals and cases has dropped since 2011 (287 in 2007 to 48 in 2019). No correlation between annual hospital procedural volume and hospital mortality was identified (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.914).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The number of hospitals treating patients requiring V\u2010V ECMO and V\u2010V ECMO cases rose from 2007 to 2019, while ECCO<jats:sub>2<\/jats:sub>R hospitals and their case numbers decreased. We detected no correlation between annual hospital V\u2010V ECMO or ECCO<jats:sub>2<\/jats:sub>R volume and hospital mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14364","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T10:04:10Z","timestamp":1657965850000},"page":"2469-2477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Annual hospital procedural volume and outcome in extracorporeal membrane oxygenation for respiratory failure"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-5228","authenticated-orcid":false,"given":"Markus","family":"J\u00e4ckel","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg University of Freiburg  Freiburg Germany"},{"name":"Faculty of Medicine, Interdisciplinary Medical Intensive Care (IMIT), Medical Center \u2010 University of Freiburg University of Freiburg  Freiburg Germany"},{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kaier","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University University of Freiburg  Freiburg Germany"},{"name":"Faculty of Medicine and Medical Center, Institute of Medical Biometry and Statistics University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-3629","authenticated-orcid":false,"given":"Jonathan","family":"Rilinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg University of Freiburg  Freiburg Germany"},{"name":"Faculty of Medicine, Interdisciplinary Medical Intensive Care (IMIT), Medical Center \u2010 University of Freiburg University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bemtgen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Interdisciplinary Medical Intensive Care (IMIT), Medical Center \u2010 University of Freiburg University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Zotzmann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Interdisciplinary Medical Intensive Care (IMIT), Medical Center \u2010 University of Freiburg University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Zehender","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg University of Freiburg  Freiburg Germany"},{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"von zur M\u00fchlen","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg University of Freiburg  Freiburg Germany"},{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stachon","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg University of Freiburg  Freiburg Germany"},{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, Center of Big Data Analysis in Cardiology (CeBAC), Heart Center Freiburg University University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bode","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, Faculty of Medicine, University Heart Center Freiburg University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Wengenmayer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Interdisciplinary Medical Intensive Care (IMIT), Medical Center \u2010 University of Freiburg University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid 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