{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:56:22Z","timestamp":1784001382884,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the synergistic effect of the new cone\u2010bearing design of Jarvik 2000 (Jarvik Heart Inc., NY) together with a minimally\u2010invasive approach to outcomes of LVAD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed all patients from 5 institutions involved in the Jarvik 2000 Italian Registry, from October 2008 to October 2016. Patients were divided into three groups according to pump design and implantation technique: pin\u2010bearing design and conventional approach (Group 1); cone\u2010bearing and conventional approach (Group 2); cone\u2010bearing and minimally\u2010invasive implantation (Group 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 150 adult patients with end\u2010stage heart failure were enrolled: 26 subjects in Group 1, 74 in Group 2, and 50 in Group 3. Nineteen patients (73%) in Group 1, 51 (69%) in Group 2, and 36 (72%) in Group 3 were discharged. During follow\u2010up, 22 patients underwent transplantation, while in 3 patients the LVAD was explanted. The overall 1\u2010year survival was 58\u2009\u00b1\u200910%, 64\u2009\u00b1\u20096%, and 74%\u2009\u00b1\u20097% in Groups 1, 2, and 3, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.034). The competing\u2010risks\u2010adjusted cumulative incidence rate for adverse events was 42.1 [27\u201362.7] per 100 patient\u2010years in Group 1, 35.4 [25.3\u201348.2] in Group 2, and 22.1 [12.4\u201336.4] in Group 3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.046 for Group 1 vs. 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association of the modern cone\u2010bearing configuration of Jarvik 2000 and minimally invasive surgery improved survival and minimized the risk for cardiovascular events, as a result of combining technology and technique.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14368","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:56:50Z","timestamp":1658480210000},"page":"2486-2492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Technology and technique for left ventricular assist device optimization: A Bi\u2010Tech solution"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-2031","authenticated-orcid":false,"given":"Vincenzo","family":"Tarzia","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-6287","authenticated-orcid":false,"given":"Matteo","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele Di","family":"Giammarco","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Maccherini","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Maiani","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-6382","authenticated-orcid":false,"given":"Piergiuseppe","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bagozzi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Apostolo","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bernazzali","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Ortis","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Di","family":"Mauro","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bortolussi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Sani","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomaso","family":"Bottio","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Scuri","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugolino","family":"Livi","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Alamanni","sequence":"additional","affiliation":[{"name":"Cardiac Surgery University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2013.09.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000743"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.09.107"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.01.086"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"621","article-title":"Jarvik 2000: evolution of surgical implantation from conventional to minimally invasive technique","volume":"3","author":"Tarzia V","year":"2014","journal-title":"Ann Cardiothorac 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