{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:35:11Z","timestamp":1782347711955,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The oxygen challenge test (OCT) is an underutilized measure of lung recovery, easily performed prior to proceeding with a trial\u2010off V\u2010V ECLS as part of a weaning algorithm. Evidence\u2010based thresholds for OCT results which support continuing with V\u2010V ECLS weaning are lacking, making interpretation of these tests challenging in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of patients commenced on V\u2010V ECLS as a bridge\u2010to\u2010recovery at Vancouver General Hospital from 2015\u20132019. The absolute PaO<jats:sub>2<\/jats:sub> post\u2010OCT and change in PaO<jats:sub>2<\/jats:sub> proportional to incremental FiO<jats:sub>2<\/jats:sub> change on the ventilator (\u2206PaO<jats:sub>2<\/jats:sub>) were evaluated as predictive screening metrics for identifying conditions favorable for successful trial\u2010off of V\u2010V ECLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An optimal cut\u2010off of PaO<jats:sub>2<\/jats:sub>\u2009\u2265\u2009240\u2009mm\u2009Hg post\u2010OCT (AUC 0.77) and \u2206PaO<jats:sub>2<\/jats:sub>\u2009\u2265\u2009250\u2009mm\u2009Hg (AUC 0.76) was identified as a threshold for predicting successful trials\u2010off. A total of 26 and 24 patients achieved post\u2010OCT PaO<jats:sub>2<\/jats:sub> and \u2206PaO<jats:sub>2<\/jats:sub> thresholds, and 100% of these patients were liberated successfully from ECLS during their admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OCT can serve as an effective screen of shunt reduction and native lung recovery which can be used alongside other measures of ventilation to assess for suitability of liberation from V\u2010V ECLS prior to a trial\u2010off. Achieving a PaO<jats:sub>2<\/jats:sub>\u2009\u2265\u2009240\u2009mm\u2009Hg post\u2010OCT is a strong prognostic indicator for successful liberation from V\u2010V ECLS during ICU admission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14382","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T05:35:16Z","timestamp":1660282516000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of successful veno\u2010venous extracorporeal life support liberation using the oxygen challenge test"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-0629","authenticated-orcid":false,"given":"Gary P.","family":"Misselbrook","sequence":"first","affiliation":[{"name":"Critical Care Medicine Vancouver General Hospital, University of British Columbia, Faculty of Medicine  Vancouver British Columbia Canada"},{"name":"School of Anaesthesia, Health Education England South East  Winchester UK"},{"name":"School of Medicine, Health Education England South East  Winchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Kanji","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Vancouver General Hospital, University of British Columbia, Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonny","family":"Thiara","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Vancouver General Hospital, University of British Columbia, Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Ronco","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Vancouver General Hospital, University of British Columbia, Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simmie","family":"Kalan","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Vancouver General Hospital, University of British Columbia, Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Vancouver General Hospital, University of British Columbia, Faculty of Medicine  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000567"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800385"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2592-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3663-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13087"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202206\u20101104ED"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001432"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502093320601"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.4.7921460"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60105-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001237"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.05.068"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.05.066"}],"container-title":["Artificial 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