{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:50:36Z","timestamp":1777405836275,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["851368 \u2010 PRE\u2010IMAGE"],"award-info":[{"award-number":["851368 \u2010 PRE\u2010IMAGE"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","award":["17OI01"],"award-info":[{"award-number":["17OI01"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The shortage of donor organs for transplantation remains a worldwide problem. The utilization of suboptimal deceased donors enlarges the pool of potential organs, yet consequently, clinicians face the difficult decision of whether these sub\u2010optimal organs are of sufficient quality for transplantation. Novel technologies could play a pivotal role in making pre\u2010transplant organ assessment more objective and reliable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ex vivo normothermic machine perfusion (NMP) at temperatures around 35\u201337\u00b0C allows organ quality assessment in a near\u2010physiological environment. Advanced magnetic resonance imaging (MRI) techniques convey unique information about an organ's structural and functional integrity. The concept of applying magnetic resonance imaging during renal normothermic machine perfusion is novel in both renal and radiological research and we have developed the first MRI\u2010compatible NMP setup for human\u2010sized kidneys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We were able to obtain a detailed and real\u2010time view of ongoing processes <jats:italic>inside<\/jats:italic> renal grafts during ex vivo perfusion. This new technique can visualize structural abnormalities, quantify regional flow distribution, renal metabolism, and local oxygen availability, and track the distribution of ex vivo administered cellular therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This platform allows for advanced pre\u2010transplant organ assessment, provides a new realistic tool for studies into renal physiology and metabolism, and may facilitate therapeutic tracing of pharmacological and cellular interventions to an isolated kidney.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14391","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T07:15:26Z","timestamp":1661238926000},"page":"105-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Magnetic resonance imaging during warm ex vivo kidney perfusion"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9461-8060","authenticated-orcid":false,"given":"Rianne","family":"Schutter","sequence":"first","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otis C.","family":"van Varsseveld","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-2825","authenticated-orcid":false,"given":"Veerle A.","family":"Lantinga","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merel B. F.","family":"Pool","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim H.","family":"Hamelink","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Hendrik","family":"Potze","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri G. D.","family":"Leuvenink","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-2911","authenticated-orcid":false,"given":"Christoffer","family":"Laustsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, The MR Research Center Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J. H.","family":"Borra","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Moers","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.01.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.07.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw054"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13523"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01395.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13441"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802289"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2006.146043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.295095034"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28363"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143607"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447601"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13292"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12031"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.07.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22387"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2382041623"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13991"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy180"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-012-0319-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000438023.02751.22"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003323"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90230.2008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn064"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.05.044"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-158"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.09.017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02924-3"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.07.23"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12660"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1482-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.2.8424343"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.395"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07900716"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ab4436"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T22:29:12Z","timestamp":1692570552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/aor.14391"],"URL":"https:\/\/doi.org\/10.1111\/aor.14391","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"2022-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}