{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:18:42Z","timestamp":1773343122127,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exercise oscillatory ventilation (EOV), indicating pathological fluctuations on pulmonary arterial pressure, is associated with mortality in patients with heart failure (HF). Whether left ventricular assist device (LVAD)\u2010induced ventricular unloading can reverse EOV and may prevent short\u2010term rehospitalization has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective single\u2010center in\u2010 and outpatient analysis of patients with (<jats:italic>n<\/jats:italic>\u00a0=\u00a020, LVAD) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a027, HF) circulatory support and reduced ejection fraction (EF, 22.8\u2009\u00b1\u20097.9%). The association of cardiopulmonary exercise testing (CPET) variables and 3\u2009months\u2010rehospitalization (3MR) as a primary outcome was analyzed. Furthermore, CPET variables were compared regarding the presence of EOV (+\/\u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower VO<jats:sub>2peak<\/jats:sub> (11.6\u2009\u00b1\u20094.9\u00a0ml\/kg\/min vs. 14.4\u2009\u00b1\u20094.3\u00a0ml\/kg\/min, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.039), lower increase of PETCO<jats:sub>2<\/jats:sub> (CI\u00a0=\u00a00.049\u20131.127; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.068), and higher VE\/VCO<jats:sub>2<\/jats:sub> (43.8\u2009\u00b1\u20099.5 vs. 38.3\u2009\u00b1\u200910.6; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.069) were associated with 3MR. Flattening of O<jats:sub>2<\/jats:sub> pulse (CI\u00a0=\u00a00.139\u20132.379; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.487) had no impact on 3MR. EOV was present in 59.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a028\/47) of patients, without a significant difference between LVAD and HF patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.959). Patients with HF\/EOV+ demonstrated significantly lower VO<jats:sub>2peak<\/jats:sub> compared with HF\/EOV\u2212 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.039). LVAD\/EOV+ displayed significantly lower EF (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and fewer aortic valve opening than LVAD\/EOV\u2212 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower VO<jats:sub>2peak<\/jats:sub>, but not EOV, was associated with 3MR. EOV occurred at a similar rate in LVAD and HF patients, which may illustrate insufficient unloading during exercise in chronic LVAD therapy and may contribute to the limited exercise capacity following LVAD implantation. Simultaneous CPET and right heart catheterization studies are needed to elucidate whether EOV may serve as a non\u2010invasive predictor of insufficient LV unloading necessitating LVAD reprograming.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14398","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T11:49:04Z","timestamp":1663156144000},"page":"168-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exercise oscillatory ventilation in patients with advanced heart failure with and without left ventricular assist device"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-0939","authenticated-orcid":false,"given":"Simon","family":"Wernhart","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart\u2010 and Vascular Center University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-7942","authenticated-orcid":false,"given":"Maria","family":"Papathanasiou","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart\u2010 and Vascular Center University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiste","family":"Jakstaite","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart\u2010 and Vascular Center University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West German Heart\u2010 and Vascular Center University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"Schmack","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic and Cardiovascular Surgery, West German Heart\u2010 and Vascular Center University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Hedderich","sequence":"additional","affiliation":[{"name":"Medistat\u2010 Biomedical Statistics Medistat GmbH  Kronshagen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjang","family":"Ruhparwar","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic and Cardiovascular Surgery, West German Heart\u2010 and Vascular Center University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[{"name":"Department of 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