{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:38:45Z","timestamp":1784309925727,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222141"],"award-info":[{"award-number":["7222141"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extracorporeal membrane oxygenation (ECMO) has salvaged many people's life during global pandemics. However, ECMO is associated with a high incidence of hemostatic complications. This study aims to explore the effects of the ECMO system on the coagulation system in the healthy ovine ECMO model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten healthy male sheep were included. Five received the veno\u2010arterial ECMO and five received the veno\u2010venous ECMO. Heparin was infused for systemic anticoagulation and was adjusted according to the activated clotting time. Blood routine tests, coagulation factors, anticoagulation proteins, and fibrinolysis markers were tested at the baseline and every 24\u2009h. After weaning, the pump heads were dissected to explore thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Platelets decreased in the first 72\u2009h and returned to the baseline at the 120th hour. The neutrophils increased in the first 24\u2009h and returned to the baseline at the 48th hour. Factors II, VII, and X decreased in the first 24\u2009h and gradually increased, while factors VIII, IX, XI, and XII decreased in the first 24\u2009h and remained at a low level. The baseline antithrombin was 73.2\u2009\u00b1\u200914.4% and reduced to 42.6\u2009\u00b1\u20099.9% at the 168th hour. Pathology showed seven sheep developed thrombus, but no clinically relevant bleeding or thrombosis events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study explored hemostatic alterations during ECMO in healthy animal models, which eliminated the confounding under critically ill conditions. The study may provide insights into ECMO hemostatic disorders and aid the design of optimal therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14437","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T06:47:02Z","timestamp":1667198822000},"page":"526-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hemostatic alterations during extracorporeal membrane oxygenation in ovine veno\u2010venous and veno\u2010arterial models"],"prefix":"10.1111","volume":"47","author":[{"given":"Sizhe","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease Chinese Academy of Medical Sciences &amp; Peking Union Medical College Fuwai Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department 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