{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:52:12Z","timestamp":1773082332809,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing peritoneal permeability with ultrafiltration and solute removal inadequacy is a challenging issue in peritoneal dialysis (PD). Decreasing permeability is less frequent but also results in diminished solute clearance. We evaluated the association between longitudinal high\u2010sensitive C\u2010reactive protein (hs\u2010CRP) values and the change in transport characteristics of the peritoneal membrane in PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective, single\u2010center study of incident PD patients. An increase or decrease in peritoneal transport status is defined as two or more categories of a rise or decline in the peritoneal equilibration test (PET) from their baseline during follow\u2010up. The 4\u2010h dialysate\/plasma creatinine ratio was used to classify transport characteristics. Hs\u2010CRP values were obtained from the routine annual examinations of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline demographics, residual kidney function, frequency of high glucose\u2010containing dialysate, and icodextrin use were similar between the groups. Total episodes of peritonitis within the first 5\u2009years of follow\u2010up were higher in stable transporters than in increased and decreased transporters (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). Stable transporters' mean hs\u2010CRP values did not change within 5\u2009years (Wilks' <jats:italic>\u03bb<\/jats:italic>\u00a0=\u00a00.873, <jats:italic>F<\/jats:italic> (2.317, 180.740)\u00a0=\u00a02.210, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.10). Increased and decreased transporters' hs\u2010CRP values significantly raised over the years (Wilks' <jats:italic>\u03bb<\/jats:italic>\u00a0=\u00a00.422, <jats:italic>F<\/jats:italic> (1.979, 77.163)\u00a0=\u00a03.405, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04 and Wilks' <jats:italic>\u03bb<\/jats:italic>\u00a0=\u00a00.558, <jats:italic>F<\/jats:italic> (3.673, 66.107)\u00a0=\u00a04.396, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that the peritoneal membrane may change into different characteristics in many patients over time, despite very low peritonitis frequencies and similar baseline characteristics that may be significantly affected by systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14438","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T15:31:24Z","timestamp":1666884684000},"page":"547-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of longitudinal high\u2010sensitive <scp>C\u2010reactive<\/scp> protein levels with changing membrane characteristics in peritoneal dialysis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-5822","authenticated-orcid":false,"given":"Berfu","family":"Korucu","sequence":"first","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil Muge","family":"Deger","sequence":"additional","affiliation":[{"name":"Department of Nephrology Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-1048","authenticated-orcid":false,"given":"Hasan","family":"Yeter","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer Faruk","family":"Akcay","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yagiz","family":"Cimen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kiraci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Giritlioglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seher","family":"Kanber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem Busra","family":"Erdemir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gazi University Faculty of Medicine  Ankara 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