{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:22:43Z","timestamp":1787235763039,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21he0422013"],"award-info":[{"award-number":["JP21he0422013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H02098"],"award-info":[{"award-number":["JP20H02098"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Mechanical circulatory support devices, such as left ventricular assist devices, have recently been used in patients with heart failure as destination therapy but the formation of thrombus in blood pumps remains a critical problem. In this study, we propose a mechanical antithrombogenic method by impeller excitation using a magnetically levitated (Maglev) centrifugal pump. Previous studies have shown that one\u2010directional excitation prevents thrombus; however, it is effective in only one direction. In this study, we aimed to obtain a better effect by vibrating it in a circular orbit to induce uniform changes in the shear\u2010rate field entirely around the impeller.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The blood coagulation time was compared using porcine blood. (1) The flow rate was set to 1\u00a0L\/min, and applied excitation was at a frequency of 280\u2009Hz and amplitude of 3\u00a0\u03bcm. (2) Moreover, the effect was compared by varying the frequency, amplitude, and direction of the excitation. In this experiment, the flow rate was set to 0.3\u00a0L\/min.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n (1) The thrombus formation time was 77\u00a0min without excitation and 133\u00a0min with excitation, which was 1.7 times longer. (2) The results showed no difference between (280\u2009Hz, 3\u00a0\u03bcm) and (50\u2009Hz, 16\u2009\u03bcm) circular orbital excitations, and no directional difference, with thrombus formation of 2.5 times longer under all conditions than that without excitation.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In the case of simple reciprocating excitation, the time was approximately 1.2 times longer. This indicated that the circular orbital excitation is more effective.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aor.14443","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T10:07:15Z","timestamp":1666951635000},"page":"425-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevention of thrombus formation in blood pump by mechanical circular orbital excitation of impeller in magnetically levitated centrifugal pump"],"prefix":"10.1111","volume":"47","author":[{"given":"Kohei","family":"Hatakenaka","sequence":"first","affiliation":[{"name":"School of Engineering Tokyo Institute of Technology Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-1919","authenticated-orcid":false,"given":"Wataru","family":"Hijikata","sequence":"additional","affiliation":[{"name":"School of Engineering Tokyo Institute of Technology Tokyo 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