{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:26:42Z","timestamp":1788827202247,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Use of veno\u2010arterial extracorporeal membrane oxygenation (VA\u2010ECMO) in elderly patients is controversial because of presumed poor outcome. Our primary aim was to determine the influence of advanced age on short\u2010 and long\u2010term outcome; the secondary aim was to analyze risk factors for impaired outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2006 and June 2020, 645 patients underwent VA\u2010ECMO implantation in our department. The patients were categorized into four groups:&lt;50, 50\u201359.9, 60\u201369.9 and \u226570\u2009years old. Data were retrospectively analyzed for short\u2010 and long\u2010term outcome. Risk factors for in\u2010hospital mortality and mortality during follow\u2010up were assessed using multivariate regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VA\u2010ECMO support duration was comparable in all age groups (median 3\u2009days). Weaning rates were 60.8%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a0104 (&lt;50\u2009years), 51.4%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a090 (50\u201359.9\u2009years), 58.8%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a0107 (60\u201369.9), and 67.5%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a079 (\u226570, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048). Hospital mortality was highest in the patients aged 50\u201359.9\u2009years (68%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a0119), but not in the elderly patients (60\u201369.9, \u226570:62.1%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a0113, 58,1%\/<jats:italic>n<\/jats:italic>\u00a0=\u00a068). At discharge, the cerebral performance category scores were superior in the patients &lt;50\u2009years. Multivariate logistic regression analysis revealed chronic kidney failure requiring hemodialysis, duration of cardiopulmonary resuscitation, and elevated blood lactate levels before VA\u2010ECMO, but not age as predictors of in\u2010hospital mortality. Cox's regression disclosed age as relevant risk factor for death during follow\u2010up. The patients' physical ability was comparable in all age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VA\u2010ECMO support should not be declined in patients only because of advanced age. Mortality and neurological status at hospital discharge and during follow\u2010up were comparable in all age groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14452","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T14:05:26Z","timestamp":1667484326000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcome after veno\u2010arterial extracorporeal membrane oxygenation in elderly patients: A 14\u2010year single\u2010center experience"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-0170","authenticated-orcid":false,"given":"Zdenek","family":"Provaznik","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Philipp","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Cardiology, Pneumology, Intensive Care University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-9903","authenticated-orcid":false,"given":"Kozakov","family":"Kostiantyn","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lunz","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-6345","authenticated-orcid":false,"given":"Bernhard","family":"Floerchinger","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"171","article-title":"Application of a mechanical heart and lung apparatus to cardiac surgery","volume":"37","author":"Gibbon JH","year":"1954","journal-title":"Minn Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2014.07.015"},{"key":"e_1_2_7_4_1","unstructured":"Extracorporeal Life Support Registry Report.2013. 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