{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:03:07Z","timestamp":1778565787171,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","award":["FF20114"],"award-info":[{"award-number":["FF20114"]}],"id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The number of patients treated by ventricular assist devices (VAD) and the duration of VAD treatment is increasing. One of the main complications in terms of morbidity and mortality for VAD patients are microbial infections. With this study, we aimed to investigate the epidemiology and microbiological characteristics of infections occurring in a VAD population to identify modifiable factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed patient characteristics, treatments and outcomes of VAD\u2010specific\/related infections. All patients implanted in our institution with a continuous flow VAD between January 2009 and January 2019 were included. Risk factors for VAD infection were assessed using simple and multiple linear regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 104 patients screened, 99 were included in the analysis, the majority of which were men (78%). At implantation, the mean age was 56\u2009years and the median time on VAD support was 541\u2009days. The overall infection rate per year per patient was 1.4. Forty\u2010seven patients (60%) suffered from VAD\u2010specific\/related infection. Half of all infection episodes occurred in the first 4\u2009months but the proportion of VAD\u2010specific\/related infection was higher after the first 4\u2009months (74% of all infection). Using regression models, no patient specific risk factors were associated with VAD\u2010specific\/related infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No predictive factors for infection during VAD support were identified in this study. By extension, diabetes, renal insufficiency, age or high BMI are not sufficient to deny a patient access to ventricular support.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14477","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T22:04:49Z","timestamp":1670450689000},"page":"898-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ten\u2010year retrospective cohort analysis of ventricular assist device infections"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-872X","authenticated-orcid":false,"given":"Giancarlo","family":"Spano","sequence":"first","affiliation":[{"name":"Centre for Advanced Heart Failure, Department of Cardiology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Buffle","sequence":"additional","affiliation":[{"name":"Centre for Advanced Heart Failure, Department of Cardiology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Na\u00ebmi","family":"Walti","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maks","family":"Mihalj","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Centre for Advanced Heart Failure, Department of Cardiology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"F\u00fcrholz","sequence":"additional","affiliation":[{"name":"Centre for Advanced Heart Failure, Department of Cardiology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yok\u2010Ai","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-1890","authenticated-orcid":false,"given":"Christopher","family":"Hayward","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Unit St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Reineke","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Hunziker","sequence":"additional","affiliation":[{"name":"Centre for Advanced Heart Failure, Department of Cardiology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-6258","authenticated-orcid":false,"given":"Bruno","family":"Schnegg","sequence":"additional","affiliation":[{"name":"Centre for Advanced Heart Failure, Department of Cardiology, Inselspital Bern University Hospital  Bern Switzerland"},{"name":"Heart Failure and Transplant Unit St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Continuous flow left ventricular assist devices: a valid option for heart failure patients","volume":"142","author":"Carrel T","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.052"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.005"},{"key":"e_1_2_8_5_1","unstructured":"National Data \u2013 OPTN.Transpl US VAD Status[cited 2019 Apr 2]. 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