{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:12:32Z","timestamp":1783962752528,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preeclampsia remains one of the most serious complications of pregnancy. Effective therapies are yet to be developed. Recent research has identified an imbalance of angiogenic and antiangiogenic factors as a root cause of preeclampsia. In particular, soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) has been shown to bind the angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), reducing blood vessel growth. Increasing preclinical and clinical evidence suggests that removal of the sFlt\u20101 protein may benefit patients with early onset preeclampsia. sFlt\u20101 may be removed by conventional blood purification techniques, such as therapeutic plasma exchange (TPE) and dextran sulfate apheresis (DSA), or emerging technologies, including extracorporeal magnetic blood purification (MBP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compare the performance and selectivity of TPE, DSA, and MBP for the therapeutic removal of sFlt\u20101. For MPB, we employ magnetic nanoparticles functionalized with either sFlt\u20101 antibodies or the sFlt\u20101\u2010binding partner, vascular endothelial growth factor (VEGF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrate that sFlt\u20101 removal by MBP is feasible and significantly more selective than TPE and DSA at comparable sFlt\u20101 removal efficiencies (MBP 96%, TPE 92%, DSA 78%). During both TPE and DSA, complement factors (incl. C3c and C4) are depleted to a considerable extent (\u221290% for TPE, \u221255% for DSA), while in MBP, complement factor concentrations remain unaltered. We further demonstrate that the removal efficacy of sFlt\u20101 in the MBP approach is strongly dependent on the nanoparticle type and dose and can be optimized to reach clinically feasible throughputs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, the highly selective removal of sFlt\u20101 and potential other disease\u2010causing factors by extracorporeal magnetic blood purification may offer new prospects for preeclamptic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14531","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T12:44:16Z","timestamp":1680180256000},"page":"1309-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Magnetic blood purification\u2010based soluble fms\u2010like tyrosine kinase\u20101 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-5002","authenticated-orcid":false,"given":"Thomas","family":"Rduch","sequence":"first","affiliation":[{"name":"Department of Gynaecology Cantonal Hospital St. Gallen  Rorschacherstrasse 95 St. Gallen Switzerland"},{"name":"Laboratory for Particles\u2010Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa)  Lerchenfeldstrasse 5 St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Arn","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology and Transplant Medicine Cantonal Hospital St.Gallen  Rorschacherstrasse 95 St.Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Kinkel","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Cantonal Hospital St. Gallen  Rorschacherstrasse 95 St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Cantonal Hospital St. Gallen  Rorschacherstrasse 95 St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Binet","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology and Transplant Medicine Cantonal Hospital St.Gallen  Rorschacherstrasse 95 St.Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hornung","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Cantonal Hospital St. Gallen  Rorschacherstrasse 95 St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-6796","authenticated-orcid":false,"given":"Inge K.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Laboratory for Particles\u2010Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa)  Lerchenfeldstrasse 5 St. Gallen Switzerland"},{"name":"Department of Mechanical and Process Engineering, ETH Zurich Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering  Sonneggstrasse 3 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.14781"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e896"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313276"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2016.10.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1429"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00165"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.034793"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21899"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2016.0048"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr02468g"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc11855b"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12380"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2016.07.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b10140"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200358"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000438"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0784-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02084"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03098"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13148"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.33"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.12.014"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201300696"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-020-00386-8"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2015-0012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2017.1279361"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21802-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112890"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701830480"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2013.784788"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2013.835820"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14531","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:43:46Z","timestamp":1780721026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/aor.14531"],"URL":"https:\/\/doi.org\/10.1111\/aor.14531","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,10]]},"assertion":[{"value":"2022-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}