{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:58:58Z","timestamp":1784091538540,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007207","name":"Toray Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The baseline endotoxin activity (EA\n                      <jats:sub>T0<\/jats:sub>\n                      ) may predict the outcome of critically ill septic patients who receive Polymyxin\u2010B hemadsorption (PMX\u2010HA), however, the clinical implications of specific EA trends remain unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Subgroup analysis of the prospective, multicenter, observational study EUPHAS2. We included 50 critically ill patients with septic shock and EA\n                      <jats:sub>T0<\/jats:sub>\n                      \u2009\u2265\u20090.6, who received PMX\u2010HA. The primary outcome of the study was the EA and SOFA score progression from T\n                      <jats:sub>0<\/jats:sub>\n                      to 120\u2009h afterwards (T\n                      <jats:sub>120<\/jats:sub>\n                      ). Secondary outcomes included the EA and SOFA score progression in whom had EA at 48\u2009h (EA\n                      <jats:sub>T48<\/jats:sub>\n                      )\u2009&lt;\u20090.6 (EA responders, EA\u2010R) versus who had not (EA non\u2010responders, EA\u2010NR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Septic shock was mainly caused by 27 abdominal (54%) and 17 pulmonary (34%) infections, predominantly due to Gram negative bacteria (39 patients, 78%). The SAPS II score was 67.5 [52.8\u201382.3] and predicted a mortality rate of 75%. Between T\n                      <jats:sub>0<\/jats:sub>\n                      and T\n                      <jats:sub>120<\/jats:sub>\n                      , the EA decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while the SOFA score and the Inotropic Score (IS) improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In comparison with EA\u2010NR (18 patients, 47%), the EA\u2010R group (23 patients, 53%) showed faster IS improvement and lower requirement of continuous renal replacement therapy (CRRT) during the ICU stay. Overall hospital mortality occurred in 18 patients (36%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In critically ill patients with septic shock and EA\n                      <jats:sub>T0<\/jats:sub>\n                      \u2009\u2265\u20090.6 who received PMX\u2010HA, EA decreased and SOFA score improved over 120\u2009h. In whom high EA resolved within 48\u2009h, IS improvement was faster and CRRT requirement was lower compared with patients with EA\n                      <jats:sub>T48<\/jats:sub>\n                      \u2009\u2265\u20090.6.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14534","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:43:56Z","timestamp":1681087436000},"page":"1361-1370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Endotoxin activity trend and multi\u2010organ dysfunction in critically ill patients with septic shock, who received Polymyxin\u2010B hemadsorption: A multicenter, prospective, observational study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-6284","authenticated-orcid":false,"given":"Salvatore Lucio","family":"Cutuli","sequence":"first","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesia Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Anesthesiology and Intensive Care Medicine Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8987-4596","authenticated-orcid":false,"given":"Silvia","family":"De\u00a0Rosa","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza  Vicenza Italy"},{"name":"Centre for Medical Sciences \u2013 CISMed University of Trento  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Intensive Care Department Vall d'Hebron University Hospital, SODIR Research Group, Vall d'Hebron Institut de Recerca  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Ruiz\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Intensive Care Department Vall d'Hebron University Hospital, SODIR Research Group, Vall d'Hebron Institut de Recerca  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Forfori","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica Universit\u00e0 di Pisa, Azienda Ospedaliero Universitaria Pisana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplantation International Renal Research Institute of Vicenza, San Bortolo Hospital  Vicenza Italy"},{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesia Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Anesthesiology and Intensive Care Medicine Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EUPHAS2\u2010G50 Collaborative Study 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