{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:06:52Z","timestamp":1785575212703,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly used due to its beneficial outcomes and results compared to conventional CPR. After cardiac arrest, the overall ejection fraction is severely impaired; thus, weaning from ECMO is often prolonged or impossible. We hypothesized that early application of levosimendan in these patients facilitates ECMO weaning and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From 2016 until 2020, patients who underwent eCPR after cardiac arrest at our institution were analyzed retrospectively and divided into two groups: patients who received levosimendan during ICU stay (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and those who did not receive levosimendan (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984) and analyzed for outcome parameters. Furthermore, we used propensity\u2010score matching and multinomial regression analysis to show the effect of levosimendan on outcome parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, in\u2010hospital mortality was significantly lower in the group which received levosimendan (28% vs. 88%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.01), and ECMO weaning was more feasible in patients who received levosimendan (88% vs. 20%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.01). CPR duration until ECMO cannulation was significantly shorter in the levosimendan group (44\u2009+\u200926 vs. 65\u2009+\u200928,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002); interestingly, the rate of mechanical chest compressions before ECMO cannulation was lower in the levosimendan group (50% vs. 69%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients after cardiac arrest treated with eCPR, levosimendan seems to contribute to higher success rates of ECMO weaning, potentially due to a short to mid\u2010term increase in inotropy. Also, the survival after levosimendan application was higher than patients who did not receive levosimendan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14540","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T01:30:10Z","timestamp":1681090210000},"page":"1351-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The impact of levosimendan on survival and weaning from\n                    <scp>ECMO<\/scp>\n                    after extracorporeal cardiopulmonary resuscitation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-3330","authenticated-orcid":false,"given":"Christopher","family":"Gaisendrees","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schlachtenberger","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Gerfer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-8218","authenticated-orcid":false,"given":"Ihor","family":"Krasivskyi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-8626","authenticated-orcid":false,"given":"Ilija","family":"Djordjevic","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sabashnikov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinos","family":"Kosmopoulos","sequence":"additional","affiliation":[{"name":"Center for Resuscitation Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine INSERM U 1116, University of Lorraine, Vand\u0153uvre\u2010l\u00e8s\u2010Nancy, France  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Luehr","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje\u2010Christin","family":"Deppe","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wahlers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne  Cologne 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