{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:25Z","timestamp":1787013865158,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012795","name":"Pritzker Institute of Biomedical Science and Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal cord injury causes a drastic loss in motor and sensory function. Intraspinal microstimulation (ISMS) is an electrical stimulation method developed for restoring motor function by activating the spinal networks below the level of injury. Current ISMS technology uses fine penetrating microwires to stimulate the ventral horn of the lumbar enlargement. The penetrating wires traverse the dura mater through a transdural conduit that connects to an implantable pulse generator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A wireless, fully intradural ISMS implant was developed to mitigate the potential complications associated with the transdural conduit, including tethering and leakage of cerebrospinal fluid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two wireless floating microelectrode array (WFMA) devices were implanted in the lumbar enlargement of an adult domestic pig. Voltage transients were used to assess the electrochemical stability of the interface. Manual flexion and extension movements of the spine were performed to evaluate the mechanical stability of the interface. Post\u2010mortem 9T MRI imaging was used to confirm the location of the electrodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The WFMA\u2010based ISMS interface successfully evoked extension and flexion movements of the hip joint. Stimulation thresholds remained stable following manual extension and flexion of the spine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preliminary results demonstrate the surgical feasibility as well as the functionality of the proposed wireless ISMS system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14562","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T06:40:10Z","timestamp":1683873610000},"page":"263-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["In\u2010vivo testing of a novel wireless intraspinal microstimulation interface for restoration of motor function following spinal cord injury"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-0403","authenticated-orcid":false,"given":"Omar","family":"Tawakol","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Illinois Institute of Technology  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Foxley","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian K.","family":"Mushahwar","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neuroscience Mental Health Institute University of Alberta  Edmonton Alberta Canada"},{"name":"Sensory Motor Adaptive Rehabilitation Technology (SMART) Network University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon L.","family":"Towle","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Troyk","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Illinois Institute of Technology  Chicago Illinois USA"},{"name":"Sensory Motor Adaptive Rehabilitation Technology (SMART) Network University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(89)90125-1"},{"issue":"11","key":"e_1_2_9_3_1","first-page":"702","article-title":"Secondary changes in segmental neurons below a spinal cord lesion in man","volume":"65","author":"Hunter J","year":"1984","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/4\/3\/S05"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53815-4.00004-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/13\/5\/056016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2016.2555959"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.3.214"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/12\/1\/016019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.876032"},{"key":"e_1_2_9_11_1","first-page":"1017","article-title":"Chronic in\u2010vivo testing of a 16\u2010channel implantable wireless neural stimulator","volume":"2015","author":"Bredeson S","year":"2015","journal-title":"Conf Proc IEEE Eng Med Biol 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