{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:42:46Z","timestamp":1775094166178,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extracorporeal life support (ECLS) for status asthmaticus (SA) is rare. Increased safety and experience may increase utilization of ECLS for SA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed pediatric (&lt;18\u2009years old) patients requiring ECLS for SA between 1998 and 2019 within the Extracorporeal Life Support Organization (ELSO) Registry and Nemours Children's Health (NCH) system. We compared patient characteristics, pre\u2010ECLS medications, clinical data, complications, and survival to discharge between <jats:italic>Early<\/jats:italic> (1988\u20132008) and <jats:italic>Late<\/jats:italic> (2009\u20132019) eras.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the ELSO Registry, we identified 173 children, 53 in <jats:italic>Early<\/jats:italic> and 120 in <jats:italic>Late<\/jats:italic> eras, with primary diagnosis of SA. Pre\u2010ECLS hypercarbic respiratory failure was similar between eras (median pH\u20097.0 and pCO<jats:sub>2<\/jats:sub> 111\u2009mm\u2009Hg). Venovenous mode (79% vs. 82%), median ECLS time (116 vs. 99\u2009h), time to extubation (53 vs. 62\u2009h), and hospital survival (89% vs. 88%) also remained similar. Intubation to cannulation time significantly decreased (20 vs. 10\u2009h, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). ECLS without complication occurred more in the <jats:italic>Late<\/jats:italic> era (19% vs. 39%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), with decreased hemorrhagic (24% vs. 12%, <jats:italic>p<\/jats:italic>\u2009=\u20090.05) and noncannula\u2010related mechanical (19% vs. 6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) complications. Within NCH, we identified six <jats:italic>Late<\/jats:italic> era patients. Pre\u2010ECLS medication favored intravenous beta agonists, bronchodilators, magnesium sulfate, and steroids. One patient died from neurological complications following pre\u2010ECLS cardiac arrest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Collective experience supports ECLS as a rescue therapy for pediatric SA. Survival to discharge remains good, and complication rates have improved. Pre\u2010ECLS cardiac arrest may potentiate neurologic injury and impact survival. Further study is needed to evaluate causal relationships between complications and outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14595","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T10:14:08Z","timestamp":1685960048000},"page":"1632-1640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pediatric extracorporeal life support for refractory status asthmaticus: ELSO Registry trends from the past decade"],"prefix":"10.1111","volume":"47","author":[{"given":"Anuradha","family":"Setlur","sequence":"first","affiliation":[{"name":"Critical Care Nemours Children's Health Delaware  Wilmington Delaware USA"},{"name":"Pediatric Critical Care Memorial Care  Fountain Valley California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa","family":"Meyer","sequence":"additional","affiliation":[{"name":"Critical Care Nemours Children's Health Delaware  Wilmington Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9656-1125","authenticated-orcid":false,"given":"Jennifer S.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Nemours Children's Health Florida  Orlando Florida USA"},{"name":"College of Medicine University of Central Florida  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Liedel","sequence":"additional","affiliation":[{"name":"Critical Care Nemours Children's Health Florida  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelyn","family":"Kahana","sequence":"additional","affiliation":[{"name":"Critical Care Nemours Children's Health Florida  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-7523","authenticated-orcid":false,"given":"Timothy M.","family":"Maul","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Nemours Children's Health Florida  Orlando Florida USA"},{"name":"College of Medicine University of Central Florida  Orlando Florida USA"},{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00526.x"},{"key":"e_1_2_8_3_1","volume-title":"NHIS asthma prevalence data. 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