{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:29:47Z","timestamp":1771849787196,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008868","name":"International Society for Heart and Lung Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mechanical circulatory support (MCS), including ventricular assist devices (VADs), have emerged as promising therapeutic alternatives for end\u2010stage congestive heart failure (CHF). The latest generation of these devices are continuous flow (CF) blood pumps. While there have been demonstrated benefits to patient outcomes due to CF\u2010MCS, there continue to be significant clinical challenges. Research to\u2010date has concentrated on mitigating thromboembolic risk (stroke), while the downstream impact of CF\u2010MCS on the cerebrospinal fluid (CSF) flow has not been well investigated. Disturbances in the CSF pressure and flow patterns are known to be associated with neurologic impairment and diseased states. Thus, here we seek to develop an understanding of the pathophysiologic consequences of CF\u2010MCS on CSF dynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We built and validated a computational framework using lumped parameter modeling of cardiovascular, cerebrovascular physics, CSF dynamics, and autoregulation. A sensitivity analysis was performed to confirm robustness of the modeling framework. Then, we characterized the impact of CF\u2010MCS on the CSF and investigated cardiovascular conditions of healthy and end\u2010stage heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Modeling results demonstrated appropriate hemodynamics and indicated that CSF pressure depends on blood flow pulsatility more than CSF flow. An acute equilibrium between CSF production and absorption was observed in the CF\u2010MCS case, characterized by CSF pressure remaining elevated, and CSF flow rates remaining below healthy, but higher than CHF states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This research has advanced our understanding of the impact of CF\u2010MCS on CSF dynamics and cerebral hemodynamics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14624","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:17:33Z","timestamp":1692670653000},"page":"1567-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of continuous\u2010flow mechanical circulatory support on cerebrospinal fluid motility"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-0856","authenticated-orcid":false,"given":"William","family":"Rose","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Applied Physiology University of Delaware  Newark Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Throckmorton","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana","family":"Heintzelman","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-3533","authenticated-orcid":false,"given":"Vakhtang","family":"Tchantchaleishvili","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs256"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12351"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CNQ.0b013e31821c622d"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCC.0000000000000454"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12644"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs-2020-cfmcs-14"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2009.2016427"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162938"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4941315"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8739"},{"key":"e_1_2_9_13_1","first-page":"129","article-title":"Fluid structure interaction model analysis of cerebrospinal fluid circulation in patients with left ventricular assist devices","volume":"16","author":"Luc JG","year":"2017","journal-title":"Int J Artif Organs"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2013.6610445"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00241.2001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00177.2005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02364625"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368459"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.2060.2007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.886874"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13080"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.053"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.125209"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2022.103851"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10558-008-9056-x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.890492"},{"key":"e_1_2_9_29_1","article-title":"Successful perioperative management of a patient with the left ventricular assist device for brain tumor resection: case report and review of the literature","volume":"2015","author":"Vandse R","year":"2015","journal-title":"Case Rep Anesthesiol"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13856"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910305116"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T12:21:56Z","timestamp":1698409316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/aor.14624"],"URL":"https:\/\/doi.org\/10.1111\/aor.14624","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}