{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:50:41Z","timestamp":1769860241048,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To explore the association between endotoxin activity (EA) and septic cardiomyopathy (SCM), the relationship between endotoxin removal by Polymyxin\u2010B hemoperfusion (PMX\u2010HP) and recovery from SCM (R\u2010SCM), and the correlation between R\u2010SCM and the 28\u2010day mortality in septic patients admitted to the intensive care unit (ICU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational study that included patients admitted to two ICUs of a tertiary university hospital between April 2011 and December 2019, who received PMX\u2010HP for sepsis\/septic shock. The SCM and R\u2010SCM were assessed by transthoracic echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 148 patients, SCM was diagnosed in 60 (46%) of them and had no relationship with median EA (SCM group: 0.73; no\u2010SCM group: 0.66, <jats:italic>p<\/jats:italic>\u2009=\u20090.48). Recovery from SCM was observed in 24 patients (49%) and was independently associated with the PMX\u2010HP (OR 4.19, 95%CI [1.22, 14.3]; <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and the SAPS2 II score (OR 0.94, 95%CI [0.9, 0.98]; <jats:italic>p<\/jats:italic>\u2009=\u20090.006). In the SCM group, the 28\u2010day mortality was 60% and was independently predicted by R\u2010SCM (OR 0.02, 95%CI [0.001, 0.3] <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and SAPS II score (OR 1.11, 95%CI [1.01, 1.23] <jats:italic>p<\/jats:italic>\u2009=\u20090.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In septic patients, EA was not associated with SCM. However, endotoxin removal by Polymyxin\u2010B hemoperfusion was associated with recovery from cardiomyopathy, which was a predictor of lower 28\u2010day mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14645","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T10:46:30Z","timestamp":1695379590000},"page":"1865-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical implications of endotoxin activity and Polymyxin\u2010B hemoperfusion in critically ill patients with septic cardiomyopathy: A single\u2010center, retrospective, observational study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-6284","authenticated-orcid":false,"given":"Salvatore Lucio","family":"Cutuli","sequence":"first","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesiology Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Institute of Anesthesiology and Intensive Care Medicine Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Carelli","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesiology Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Institute of Anesthesiology and Intensive Care Medicine Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cascarano","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesiology Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Institute of Anesthesiology and Intensive Care Medicine Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Cicconi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Infermi Hospital  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine S. Luca Hospital  Lucca Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Cicetti","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesiology Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Institute of Anesthesiology and Intensive Care Medicine Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Sole","family":"Vallecoccia","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Santa Maria Nuova Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Pintaudi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Intensive Care Medicine and Anesthesiology Fondazione Policlinico Universitario A. 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