{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:19:07Z","timestamp":1787732347250,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left ventricular assist device (LVAD) is associated with a high incidence of right ventricular (RV) failure, which is hypothesized to be caused by the occurring inter\u2010ventricular interactions when the LV is unloaded. Factors contributing to these interactions are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used computer modeling to investigate the impact of the HeartMate 3 LVAD on RV functions. The model was first calibrated against pressure\u2013volume (PV) loops associated with a heart failure (HF) patient and validated against measurements of inter\u2010ventricular interactions in animal experiments. The model was then applied to investigate the effects of LVAD on (1) RV chamber contractility indexed by  derived from its end\u2010systolic PV relationship, and (2) RV diastolic function indexed by  derived from its end\u2010diastolic PV relationship. We also investigated how septal wall thickness and regional contractility affect the impact of LVAD on RV function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The impact of LVAD on RV chamber contractility is small at a pump speed lower than 4k\u2009rpm. At a higher pump speed between 4k and 9k\u2009rpm, however, RV chamber contractility is reduced (by ~3% at 6k\u2009rpm and ~10% at 9k\u2009rpm). The reduction of RV chamber contractility is greater with a thinner septal wall or with a lower myocardial contractility at the LV free wall, septum, or RV free wall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RV chamber contractility is reduced at a pump speed higher than 4k\u2009rpm, and this reduction is greater with a thinner septal wall or lower regional myocardial contractility. Findings here may have clinical implications in identifying LVAD patients who may suffer from RV failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14649","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T10:14:40Z","timestamp":1695636880000},"page":"1831-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An in silico study of the effects of left ventricular assist device on right ventricular function and inter\u2010ventricular interaction"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-1277","authenticated-orcid":false,"given":"Lei","family":"Fan","sequence":"first","affiliation":[{"name":"Joint Department of Biomedical Engineering Marquette University and Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny S.","family":"Choy","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medicine, Advanced Heart Failure and Transplantation Spectrum Health Meijer Heart &amp; Vascular Institute  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Physiology and Cardiovascular Medicine University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"Wenk","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan S.","family":"Kassab","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lik Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.09.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)01056-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1987.253.6.H1381"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1967.213.3.711"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.04.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.105050"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.744855"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mechrescom.2019.04.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-021-10130-y"},{"key":"e_1_2_8_11_1","unstructured":"NicksonC.Ventricular assist device (VAD).2015. Available from:https:\/\/litfl.com\/ventricular\u2010assist\u2010device\u2010vad\/"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"A multiphysics biventricular cardiac model: simulations with a left\u2010ventricular assist device","volume":"9","author":"Bakir AA","year":"2018","journal-title":"Front Physiol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.608"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2690"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euromechsol.2014.03.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.085"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00703.2020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114978"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000053947.82595.03"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20104975(93)90402\u20104"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00520"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000520"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000396"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.018"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.11.599"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1029"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90068-0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.3.1200"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2003.60"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.959288"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MAT.0000104819.23235.2F"},{"key":"e_1_2_8_33_1","first-page":"S52","article-title":"Right heart failure post left ventricular assist device implantation","volume":"6","author":"Argiriou M","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.006994"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.107188"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00549.2020"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.24.3.339"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2894084"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2895474"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T10:24:27Z","timestamp":1704709467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/aor.14649"],"URL":"https:\/\/doi.org\/10.1111\/aor.14649","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]},"assertion":[{"value":"2023-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}