{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:42:47Z","timestamp":1780522967540,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastrointestinal bleeding (GIB) in patients with continuous flow left ventricular assist devices (CF\u2010LVADs) is often related to GI angiodysplasia (GIAD). We previously reported data on VEGF inhibition with IV bevacizumab in the treatment of LVAD\u2010associated GIAD bleeding, and now present follow\u2010up data on patients treated with IV bevacizumab and\/or low\u2010dose oral pazopanib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive adult patients with LVAD\u2010associated GIB from GIAD treated with bevacizumab or pazopanib, from July 20, 2017 to June 22, 2022, were included in the analysis. Data on hospitalizations, GI endoscopic procedures, and blood transfusions were obtained from first admission for GIB up to a median of 35.7\u2009months following treatment initiation (range 1.3\u201359.8\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients (91% male, mean 69.5\u2009\u00b1\u20098.9\u2009years) were included. Eight patients (73%) received IV bevacizumab, two patients (18%) received oral pazopanib, and one patient (9%) received bevacizumab followed by pazopanib therapy. We observed a significantly decreased number of annualized hospitalizations for GIB (median difference\u2009\u2212\u20092.87, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), blood transfusions (median difference\u2009\u2212\u200920.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), and endoscopies (median difference\u2009\u2212\u20096.95, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) in patients pre\u2010 and post\u2010anti\u2010angiogenic therapy (bevacizumab and\/or pazopanib). Similarly, a significant improvement in these clinical outcomes was noted in the bevacizumab group with decreased annualized hospitalizations (median difference\u2009\u2212\u20092.75, <jats:italic>p<\/jats:italic>\u2009=\u20090.014), blood transfusions (median difference\u2009\u2212\u200924.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.047), and number of endoscopies (median differences \u22126.88, <jats:italic>p<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010angiogenic therapy with IV bevacizumab and\/or low\u2010dose oral pazopanib appears to provide benefits in patients with LVAD\u2010associated GIB with reduced hospitalizations, blood transfusions, and need for GI endoscopic procedures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14694","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T13:04:58Z","timestamp":1703250298000},"page":"646-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of angiogenesis in the management of refractory gastrointestinal bleeding in patients with <scp>LVAD<\/scp> support"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3200-3575","authenticated-orcid":false,"given":"Sara S.","family":"Inglis","sequence":"first","affiliation":[{"name":"Van Cleve Cardiac Regenerative Medicine Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Asleh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek N.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-1494","authenticated-orcid":false,"given":"Sarah D.","family":"Schettle","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio A.","family":"Villavicencio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Rodeheffer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir S.","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atta","family":"Behfar","sequence":"additional","affiliation":[{"name":"Van Cleve Cardiac Regenerative Medicine Program Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9202-0233","authenticated-orcid":false,"given":"Andrew N.","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Van Cleve Cardiac Regenerative Medicine Program Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota 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