{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:16:22Z","timestamp":1790914582107,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The level of bacteremia in patients with sepsis and septic shock is a predictor of complications and mortality, regardless of the type of bacteria. Devices for bacteria, endotoxin and cytokines removal by adsorption have been recently developed. Thus, extracorporeal blood purification therapies have been proposed as adjunctive therapy in sepsis in combination with drugs. Some potentially useful drugs, however, are precluded due to their organ or metabolic toxicity. The present study represents a preliminary report on the in\u00a0vitro effect of a sorbent device (minimodule with HA380 beads, Jafron medical, Zhuhai, China) in which the particles have been functionalized with vancomycin on the surface. The impact of the surface\u2010modified beads on circulating bacteria (\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      ) has been tested in a simulated in\u00a0vitro circulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In vitro experiments were carried out with 800\u2009mL of blood enriched with\n                      <jats:italic>S. aureus<\/jats:italic>\n                      species. Blood was circulated in the vancomycin\u2010functionalized and non\u2010functionalized mini\u2010module cartridges in hemoadsorption setup (300\u2009mL each) and the bactericidal effect was assessed. Also, 200\u2009mL of blood was used as a control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant increase in the time to positivity of blood cultures was observed after 60\u2009min and also after 120\u2009min of therapy with the mini\u2010module functionalized with vancomycin as opposed to the non\u2010functionalized cartridge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results suggest a possible way of treating sepsis by using drug\u2010 or antibiotic\u2010functionalized cartridges without worrying about pharmacological toxicity. The prolongation of the time to bacterial culture positivity to\n                      <jats:italic>S. aureus<\/jats:italic>\n                      after a passage through a column packed with beads functionalized with vancomycin represents a proof of concept.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14704","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T03:55:19Z","timestamp":1703822119000},"page":"543-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sorbent functionalization with vancomycin enhances bacteria killing in extracorporeal hemoadsorption"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-9997","authenticated-orcid":false,"given":"Gonzalo","family":"Ram\u00edrez\u2010Guerrero","sequence":"first","affiliation":[{"name":"International Renal Research Institute of Vicenza (IRRIV Foundation)  Vicenza Italy"},{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"},{"name":"Department of Medicine Universidad de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"de Cal","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza (IRRIV Foundation)  Vicenza Italy"},{"name":"Department of Nephrology, Dialysis and Kidney Transplantation San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-2359","authenticated-orcid":false,"given":"Anna","family":"Lorenzin","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza (IRRIV Foundation)  Vicenza Italy"},{"name":"Department of Nephrology, Dialysis and Kidney Transplantation San Bortolo Hospital  Vicenza 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Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza (IRRIV Foundation)  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7571"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw207"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2011.01445.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.17.2066"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05022-11"},{"key":"e_1_2_12_7_1","first-page":"263","article-title":"Bacteremia, sepsis, and infective endocarditis associated with Staphylococcus 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