{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:29:31Z","timestamp":1786512571038,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left ventricular assist device (L\u2010VAD) implantation is increasingly used in patients with heart failure (HF) and most patients also have an implantable cardioverter defibrillator (ICD). Limited data are available on the incidence of ICD therapies and complications in this special setting.<\/jats:p>\n                    <jats:p>The aim of this study was to analyze the real\u2010world incidence and predictors of ICD therapies, complications and interactions between ICD and L\u2010VAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective observational study in patients with advanced HF implanted with ICD and a continuous\u2010flow L\u2010VAD, followed\u2010up in five advanced HF centers in Northern Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 234 patients (89.7% male, median age 59, 48.3% with ischemic etiology) were enrolled. After a median follow\u2010up of 21\u2009months, 66 patients (28.2%) experienced an appropriate ICD therapy, 22 patients (9.4%) an inappropriate ICD therapy, and 17 patients (7.3%) suffered from an interaction between ICD and L\u2010VAD. The composite outcome of all ICD\u2010related complications was reported in 41 patients (17.5%), and 121 (51.7%) experienced an L\u2010VAD\u2010related complication. At multivariable analysis, an active ventricular tachycardia (VT) zone and a prior ICD generator replacement were independent predictors of ICD therapies and of total ICD\u2010related complications, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010world patients with both L\u2010VAD and ICD experience a high rate of ICD therapies and complications. Our findings suggest the importance of tailoring device programming in order to minimize the incidence of unnecessary ICD therapies, thus sparing the need for ICD generator replacement, a procedure associated to a high risk of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14708","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T03:28:56Z","timestamp":1705030136000},"page":"525-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010world data of patients affected by advanced heart failure treated with implantable cardioverter defibrillator and left ventricular assist device: Results of a multicenter observational study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4111-1690","authenticated-orcid":false,"given":"Roberto","family":"Rordorf","sequence":"first","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit IRCCS Fondazione Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pignalosa","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit IRCCS Fondazione Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-7484","authenticated-orcid":false,"given":"Matteo","family":"Casula","sequence":"additional","affiliation":[{"name":"Arrhythmia and Electrophysiology Unit IRCCS Fondazione Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Perna","sequence":"additional","affiliation":[{"name":"De Gasperis CardioCenter Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Baroni","sequence":"additional","affiliation":[{"name":"De Gasperis CardioCenter Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Garascia","sequence":"additional","affiliation":[{"name":"De Gasperis CardioCenter Niguarda Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Guida","sequence":"additional","affiliation":[{"name":"Division of Cardiology IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Gazzoli","sequence":"additional","affiliation":[{"name":"Division Cardiac Surgery IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Perioperative Cardiology and Cardiovascular imaging, Centro Cardiologico Monzino IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-5293","authenticated-orcid":false,"given":"Francesco","family":"Cannata","sequence":"additional","affiliation":[{"name":"Department of Perioperative Cardiology and Cardiovascular imaging, Centro Cardiologico Monzino IRCCS  Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Perioperative Cardiology and Cardiovascular imaging, Centro Cardiologico Monzino IRCCS  Milan 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