{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:30:10Z","timestamp":1792024210743,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to identify predictors of early tumor recurrence in patients with hepatocellular carcinoma (HCC) after liver transplantation (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study in 237 consecutive liver recipients with HCC between 2016 and 2021. Multivariate logistic analysis was performed to identify predictors of early HCC recurrences. The impact of hypothermic\u2010oxygenated perfusion (HOPE) on outcome was analyzed after propensity score weighting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early recurrences were observed in 15 cases. Microvascular invasion (OR 3.737, 95% CI 1.246\u201311.206, <jats:italic>p<\/jats:italic>\u2009=\u20090.019) and cold ischemia time (OR 1.155, 95% CI 1.001\u20131.333, <jats:italic>p<\/jats:italic>\u2009=\u20090.049) were independently associated with a lower risk of HCC recurrences. After balancing for relevant variables, patients in the HOPE group had lower rates of tumor recurrence (weighted OR 0.126, 95% CI 0.016\u20130.989, <jats:italic>p<\/jats:italic>\u2009=\u20090.049) and higher recurrence free survival (weighted HR 0.132, 95% CI 0.017\u20130.999, <jats:italic>p<\/jats:italic>\u2009=\u20090.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reducing cold ischemia time and graft perfusion with HOPE can lead to lower rates of early HCC recurrences and higher recurrence\u2010free survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14715","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T14:29:20Z","timestamp":1706192960000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of cold ischemia time and hypothermic perfusion in predicting early hepatocellular carcinoma recurrences after liver transplantation"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-4524","authenticated-orcid":false,"given":"Gerti","family":"Dajti","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-1956","authenticated-orcid":false,"given":"Giuliana","family":"Germinario","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna Italy"},{"name":"General Surgery and Transplantation Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-1812","authenticated-orcid":false,"given":"Enrico","family":"Prosperi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical 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