{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:21:40Z","timestamp":1790083300581,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of extracorporeal membrane oxygenation (ECMO) as a bridge to left ventricular assist device (LVAD) remains unclear, and recipients of the more contemporary HeartMate 3 (HM3) LVAD are not well represented in previous studies. We therefore undertook a multicenter, retrospective study of this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>INTERMACS 1 LVAD recipients from five U.S. centers were included. In\u2010hospital and one\u2010year outcomes were recorded. The primary outcome was the overall mortality hazard comparing ECMO versus non\u2010ECMO patients by propensity\u2010weighted survival analysis. Secondary outcomes included survival by LVAD type, as well as postoperative and one\u2010year outcomes. One hundred and twenty\u2010seven patients were included; 24 received ECMO as a bridge to LVAD. Mortality was higher in patients bridged with ECMO in the primary analysis (HR 3.22 [95%CI 1.06\u20139.77], <jats:italic>p<\/jats:italic>\u2009=\u20090.039). Right ventricular assist device was more common in the ECMO group (ECMO: 54.2% vs non\u2010ECMO: 11.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Ischemic stroke was higher at one year in the ECMO group (ECMO: 25.0% vs non\u2010ECMO: 4.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Among the study cohort, one\u2010year mortality was lower in HM3 than in HeartMate II (HMII) or HeartWare HVAD (10.5% vs 46.9% vs 31.6%, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) recipients. Pump thrombosis at one year was lower in HM3 than in HMII or HVAD (1.8% vs 16.1% vs 16.2%, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.026) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher mortality was observed with ECMO as a bridge to LVAD, likely due to higher acuity illness, yet acceptable one\u2010year survival was seen compared with historical rates. The receipt of the HM3 was associated with improved survival compared with older generation devices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14740","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T07:38:34Z","timestamp":1709969914000},"page":"921-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multicenter evaluation of left ventricular assist device implantation with or without <scp>ECMO<\/scp> bridge in cardiogenic shock"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-4604","authenticated-orcid":false,"given":"James W.","family":"Schurr","sequence":"first","affiliation":[{"name":"Hospital of the University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Ambrosi","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Stony Brook University Hospital Renaissance School of Medicine at Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Genuardi","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Brahier","sequence":"additional","affiliation":[{"name":"Medstar Washington Hospital Center Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Elliot","sequence":"additional","affiliation":[{"name":"Medstar Washington Hospital Center Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-3166","authenticated-orcid":false,"given":"Kevin","family":"McGowan","sequence":"additional","affiliation":[{"name":"Medstar Washington Hospital Center Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-5044","authenticated-orcid":false,"given":"Akram","family":"Zaaqoq","sequence":"additional","affiliation":[{"name":"UVA Health University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonjoy","family":"Laskar","sequence":"additional","affiliation":[{"name":"Emory University Hospital Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Pope","sequence":"additional","affiliation":[{"name":"Emory University Hospital Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Givertz","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Mallidi","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn 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