{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:24Z","timestamp":1747183284832,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite combined anticoagulation therapy consisting of a vitamin K antagonist and an antiplatelet agent, thromboembolic complications often occur in patients with a left ventricular assist device (LVAD). In addition, bleeding events are also common. Resistance to antiplatelet drugs is a well\u2010known phenomenon; however, the utilization of laboratory chemistry testing for the presence of such resistance, and then switching therapy, is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested 132 patients with LVAD (HeartWare <jats:italic>n<\/jats:italic>\u2009=\u200957, HeartMate II <jats:italic>n<\/jats:italic>\u2009=\u200922, HeartMate 3 <jats:italic>n<\/jats:italic>\u2009=\u200953) on acetylsalicylic acid (ASA) therapy for resistance and followed them for a maximum of 7\u2009years regarding pump thrombosis. Light transmission aggregometry (LTA) and impedance aggregometry (IPA) were performed for testing platelet function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We could show that patients with ASA resistance displayed an increased risk of pump thrombosis, regardless of the test used (LTA: OR\u2009=\u20096.20, CI [1.86\u201320.64], <jats:italic>p<\/jats:italic>\u2009=\u20090.003; IPA: OR\u2009=\u200912.14, CI [3.00\u201349.07], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In patients with a HeartMate 3, we could not detect any pump thrombosis associated with aspirin resistance. Furthermore, there was no significant difference in bleeding events between patients with ASA resistance and ASA responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laboratory testing of ASA resistance seems to be a good tool to detect an increased risk of pump thrombosis, at least for patients with a HeartWare or HeartMate II. The extent to which these thromboses can be prevented with a change of medication has to be investigated in further studies. No pump thrombosis was detected in patients with a HeartMate 3, and the question should be asked as to what constellation of underlying and concomitant diseases must be present to justify ASA therapy for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14742","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T08:45:10Z","timestamp":1711788310000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aspirin resistance in patients with ventricular assist devices: A follow\u2010up study"],"prefix":"10.1111","volume":"48","author":[{"given":"Tobias","family":"Flieder","sequence":"first","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Institut f\u00fcr Laboratoriums\u2010 und Transfusionsmedizin  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Blaesen","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Institut f\u00fcr Laboratoriums\u2010 und Transfusionsmedizin  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Schulte","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Institut f\u00fcr Laboratoriums\u2010 und Transfusionsmedizin  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jost","family":"Blasberg","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Psychosoziale Medizin, Psychotherapie und Psychoonkologie Universit\u00e4tsklinikum Jena, Friedrich\u2010Schiller\u2010Universit\u00e4t  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Lauenroth","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Klinik f\u00fcr Thorax\u2010 und Kardiovaskularchirurgie  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Knabbe","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Institut f\u00fcr Laboratoriums\u2010 und Transfusionsmedizin  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Schramm","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Klinik f\u00fcr Thorax\u2010 und Kardiovaskularchirurgie  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Morshuis","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Klinik f\u00fcr Thorax\u2010 und Kardiovaskularchirurgie  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gummert","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Klinik f\u00fcr Thorax\u2010 und Kardiovaskularchirurgie  Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-0483","authenticated-orcid":false,"given":"Ingvild","family":"Birschmann","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum Nordrhein\u2010Westfalen Universit\u00e4tsklinik der Ruhr\u2010Universit\u00e4t Bochum, Institut f\u00fcr Laboratoriums\u2010 und Transfusionsmedizin  Bad Oeynhausen 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