{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:43:16Z","timestamp":1789512196261,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Stroke after durable left ventricular assist device (d\u2010LVAD) implantation portends high mortality. The incidence of ischemic and hemorrhagic stroke and the impact on stroke outcomes of temporary mechanical circulatory support (tMCS) management among patients requiring bridge to d\u2010LVAD with micro\u2010axial flow\u2010pump (mAFP, Abiomed) is unsettled.<\/jats:p><\/jats:sec>Methods<\/jats:title>Consecutive patients, who underwent d\u2010LVAD implantation after being bridged with mAFP at 19 institutions, were retrospectively included. The incidence of early ischemic and hemorrhagic stroke after d\u2010LVAD implantation (<60\u2009days) and association of pre\u2010d\u2010LVAD characteristics and peri\u2010procedural management with a specific focus on tMCS strategies were studied.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 341 patients, who underwent d\u2010LVAD implantation after mAFP implantation (male gender 83.6%, age 58 [48\u201365] years, mAFP 5.0\/5.5 72.4%), the early ischemic stroke incidence was 10.8% and early hemorrhagic stroke 2.9%. The tMCS characteristics (type of mAFP device and access, support duration, upgrade from intra\u2010aortic balloon pump, ECMELLA, ECMELLA at d\u2010LVAD implantation, hemolysis, and bleeding) were not associated with ischemic stroke after d\u2010LVAD implant. Conversely, the device model (mAFP 2.5\/CP vs. mAFP 5.0\/5.5: HR 5.6, 95%CI 1.4\u201322.7, p<\/jats:italic>\u2009=\u20090.015), hemolysis on mAFP support (HR 10.5, 95% CI 1.3\u201385.3, p<\/jats:italic>\u2009=\u20090.028) and ECMELLA at d\u2010LVAD implantation (HR 5.0, 95% CI 1.4\u201318.7, p<\/jats:italic>\u2009=\u20090.016) were associated with increased risk of hemorrhagic stroke after d\u2010LVAD implantation. Both early ischemic (HR 2.7, 95% CI 1.9\u20134.5, p<\/jats:italic>\u2009<\u20090.001) and hemorrhagic (HR 3.43, 95% CI 1.49\u20137.88, p<\/jats:italic>\u2009=\u20090.004) stroke were associated with increased 1\u2010year mortality.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Among patients undergoing d\u2010LVAD implantation following mAFP support, tMCS characteristics do not impact ischemic stroke occurrence, while several factors are associated with hemorrhagic stroke suggesting a proactive treatment target to reduce this complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14775","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T06:52:06Z","timestamp":1716879126000},"page":"1168-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Stroke outcomes following durable left ventricular assist device implant in patients bridged with micro\u2010axial flow pump: Insights from a large registry"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"first","affiliation":[{"name":"City of Health and Science Hospital, Division of Cardiology, Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-6289","authenticated-orcid":false,"given":"Daniel","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC) Berlin Germany"},{"name":"Department of Cardiovascular Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rojas\u00a0Hernandez","sequence":"additional","affiliation":[{"name":"Heart and Diabetes Center North Rhine\u2010Westphalia 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