{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:51:00Z","timestamp":1793656260108,"version":"4.5.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypothermic Oxygenated machine PErfusion (HOPE) can reduce ischemic reperfusion injury and improve outcomes for liver transplant recipients. However, the effect of HOPE on high\u2010risk extended criteria donor (ECD) and donation after circulatory death determination (DCDD) grafts is incomplete, despite the expectation that this cohort benefit maximally from HOPE. Accordingly, this paper aims to characterize the effect of HOPE on ECD and DCDD grafts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study includes all papers comparing HOPE to static cold storage for high\u2010risk ECD and DCDD grafts. Systematic searches of Medline, Embase, and Scopus were completed using the terms \u201cHOPE\u201d OR \u201chypothermic oxygenated machine perfusion\u201d AND \u201cliver transplantation\u201d. Data were extracted and analyzed using IBM SPSS to perform the meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2286 records were identified, with 10 meeting the inclusion criteria. Overall, the quality of evidence is heterogenous with many papers relying on retrospective controls. However, pooled analysis demonstrates HOPE to significantly reduce the rate of early allograft dysfunction, 12\u2010month graft failure, re\u2010transplantation, total biliary complications, and non\u2010anastomotic strictures for high\u2010risk grafts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is good evidence that HOPE improves outcomes following liver transplantation across a number of biochemical and clinical endpoints for high\u2010risk grafts. Of note, the reduction in biliary complications and re\u2010transplantation is particularly significant given the morbidity associated with these endpoints. However, further, high\u2010quality prospective trials with contemporary controls and clinically relevant primary endpoints are needed to better define the impact of HOPE for this cohort of grafts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14814","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T04:29:47Z","timestamp":1719030587000},"page":"1085-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hypothermic Oxygenated machine PErfusion for high\u2010risk liver grafts for transplantation: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7072-2160","authenticated-orcid":false,"given":"Charles W. G.","family":"Risbey","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Centre for Organ Assessment, Repair, &amp; Optimization (COARO) Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Royal Prince Alfred Hospital Transplant Institute (RPATI), Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Thomas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-3240","authenticated-orcid":false,"given":"Anita","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Centre for Organ Assessment, Repair, &amp; 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