{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:35Z","timestamp":1747183295581,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010left ventricular assist device (LVAD) pectoralis muscle assessment, an estimate of sarcopenia, has been associated with postoperative mortality and gastrointestinal bleeding, though its association with inflammation, endotoxemia, length\u2010of\u2010stay (LOS), and readmissions remains underexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center cohort study of LVAD patients implanted 1\/2015\u201310\/2018. Preoperative pectoralis muscle area was measured on chest computed tomography (CT), adjusted for height squared to derive pectoralis muscle area index (PMI). Those with PMI in the lowest quintile were defined as <jats:italic>low\u2010PMI<\/jats:italic> cohort; all others constituted the reference cohort. Biomarkers of inflammation (interleukin\u20106, adiponectin, tumor necrosis factor\u2010\u03b1 [TNF\u03b1]) and endotoxemia (soluble (s)CD14) were measured in a subset of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 254 LVAD patients, 95 had a preoperative chest CT (median days pre\u2010LVAD: 7 [IQR 3\u201313]), of whom 19 (20.0%) were in the low\u2010PMI cohort and the remainder were in the reference cohort. Compared with the reference cohort, the <jats:italic>low\u2010PMI<\/jats:italic> cohort had higher levels of sCD14 (2594 vs. 1850\u2009ng\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and TNF\u03b1 (2.9 vs. 1.9\u2009pg\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). In adjusted analyses, the <jats:italic>low\u2010PMI<\/jats:italic> cohort had longer LOS (incidence rate ratio 1.56 [95% confidence interval 1.16\u20132.10], <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and higher risk of 90\u2010day and 1\u2010year readmissions (subhazard ratio 5.48 [1.88\u201316.0], <jats:italic>p<\/jats:italic>\u2009=\u20090.002; hazard ratio 1.73 [1.02\u20132.94]; <jats:italic>p<\/jats:italic>\u2009=\u20090.04, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010LVAD PMI is associated with inflammation, endotoxemia, and increased LOS and readmissions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14836","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T07:19:10Z","timestamp":1722669550000},"page":"1494-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010operative pectoralis muscle area index is associated with biomarkers of inflammation and endotoxemia and predicts clinical outcomes after left ventricular assist device implantation: A cohort study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-8437","authenticated-orcid":false,"given":"Matthew R.","family":"Carey","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Ladanyi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa","family":"Driggin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhana","family":"Latif","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel T.","family":"Sayer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Clerkin","sequence":"additional","affiliation":[{"name":"Division of 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