{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:45:17Z","timestamp":1792089917592,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The SynCardia\u00ae temporary total artificial heart (TAH) serves as a mechanical circulatory support device for patients suffering from irreversible biventricular failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed 196 consecutive patients who underwent TAH implantation at our center from 2001 to 2021. We assessed survival rates and all\u2010cause mortality during TAH support, including survival post\u2010heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of patients was 55\u2009years, with 88% being male. The primary diagnoses included cardiomyopathy (43.9%), acute myocardial infarction (26.5%), and postcardiotomy heart failure (15.5%). At implantation, 87.2% of patients were classified as INTERMACS Profile 1. The median duration of support was 96\u2009days (IQR: 23\u2013227). Survival rates at 1, 6, and 12\u2009months were 72%, 41%, and 34%, respectively. Postoperative rethoracotomy was necessary in 44.4% of patients; 39.3% experienced neurological events and 24.6% developed gastrointestinal bleeding. Overall, 64.8% of patients died while on support, primarily due to multiple organ failure (55.9%). Factors such as older age, higher bilirubin levels, postcardiotomy and specific underlying diagnoses were independent predictors of mortality during TAH support. On a positive note, 35.2% of patients underwent successful heart transplants, with 1\u2010, 5\u2010, and 10\u2010year posttransplant survival rates of 65%, 58%, and 51%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While high mortality rates persist among patients with biventricular failure, the SynCardia\u00ae TAH offers a viable interim solution for critically ill patients, particularly those who can be successfully bridged to heart transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14860","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T13:04:22Z","timestamp":1726491862000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcomes after <scp>SynCardia<\/scp>\u00ae temporary total artificial heart implantation: A 20\u2010year single\u2010center experience in 196\u00a0patients"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5782-7977","authenticated-orcid":false,"given":"Artyom","family":"Razumov","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine\u2010Westphalia Ruhr University of Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchior","family":"Burri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Zittermann","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine\u2010Westphalia Ruhr University of Bochum  Bad Oeynhausen 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