{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:00Z","timestamp":1787509260023,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Impella 5.5 is a temporary left ventricular assist device utilized to support patients with cardiogenic shock and those undergoing high\u2010risk cardiac interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From October 2019 to January 2023, 226 patients received Impella 5.5 support at Cleveland Clinic main campus. Patients were stratified by Society for Cardiovascular Angiography and Interventions (SCAI) shock stages. Immediate post\u2010Impella 5.5 trajectories were compared across groups. Trajectories were defined as mortality on Impella 5.5, transition to advanced heart failure therapies (durable left ventricular assist device\/heart transplantation), or survival to Impella 5.5 removal without advanced therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 148 (65%) patients with cardiogenic shock and 78 (35%) undergoing high\u2010risk cardiac interventions received Impella 5.5 support. SCAI stage was A in 63 (28%), B in 10 (4.4%), C in 29 (13%), D in 104 (46%), and E in 20 (8.8%). Mortality on Impella 5.5 was highest in SCAI stage E (A: 3.2%, B: 10%, C: 14%, D: 27%, E: 35%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Transition to advanced therapies (durable left ventricular assist device or heart transplantation) was highest in SCAI stages C\u2010D (A: 1.6%, B: 0.0%, C: 45%, D: 36%, E: 20%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Survival to Impella removal without advanced therapies was highest in SCAI stages A\u2010B (A: 95%, B: 90%, C: 41%, D: 38%, E: 45%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stratification by presentation acuity in candidates for Impella 5.5 insertion may help identify which patients may and may not benefit from this escalation of tailored temporary mechanical circulatory support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14867","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:43:48Z","timestamp":1729233828000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Trajectories following Impella 5.5 support are associated with initial presentation acuity"],"prefix":"10.1111","volume":"49","author":[{"given":"Jean\u2010Luc A.","family":"Maigrot","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall C.","family":"Starling","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Soltesz","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Smedira","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Z. Y.","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Unai","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moros","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene H.","family":"Blackstone","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Quantitative Health Sciences Lerner Research Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Kaufman Center for Heart Failure Treatment and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2023.01.011"},{"key":"e_1_2_9_3_1","article-title":"Surgically implanted endovascular, micro axial left ventricular assist device: a single institution study","author":"Schumer EM","year":"2023","journal-title":"JTCVS Techniques"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15066"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.02.015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28329"},{"key":"e_1_2_9_8_1","volume-title":"R: a language and environment for statistical computing","author":"R Core 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