{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:46:16Z","timestamp":1772030776192,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aortic regurgitation (AR) is a known complication after left ventricular assist device (LVAD) implantation potentially leading to recurrent heart failure. Possible pathomechanisms include valvular pathologies and aortic root dilatation. We assessed aortic root dimensions in a group of consecutive LVAD patients who received HeartMate 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Since 11\/2015, we identified 68 patients with no or mild AR at the time of HeartMate 3 implantation who underwent serial echocardiography to assess AR and aortic root dimensions (annulus, sinus, and sinotubular junction). Median follow\u2010up was 40\u2009months (2\u201394\u2009months). Results were correlated with clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were 60\u2009\u00b1\u200910\u2009years old, predominantly male (88%) and 35% presented in preoperative critical condition as defined by INTERMACS levels 1 and 2. During follow\u2010up, 23 patients developed AR \u2265 II (34%). Actuarial incidence was 8% at 1\u2009year, 29% at 3\u2009years and 41% at 5\u2009years. Echocardiography revealed practically stable root dimensions at the latest follow\u2010up compared to the preoperative state (annulus: 23\u2009\u00b1\u20093\u2009mm vs. 23\u2009\u00b1\u20092\u2009mm, sinus: 32\u2009\u00b1\u20094\u2009mm vs. 33\u2009\u00b1\u20093\u2009mm, sinotubular junction: 27\u2009\u00b1\u20093\u2009mm vs. 28\u2009\u00b1\u20093\u2009mm), irrespective of the development of AR. Serial CT angiograms were performed in 13 patients to confirm echocardiographic findings. Twenty\u2010one patients died during LVAD support leading to a 5\u2010year survival of 71%, showing no difference between patients with and without AR \u2265 II (<jats:italic>p<\/jats:italic>\u2009=\u20090.573).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At least moderate AR develops over time in a substantial fraction of patients (one\u2010third over 3\u2009years). The mechanism does not seem to be related to dilatation of the aortic annulus or root.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14873","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:28:48Z","timestamp":1727699328000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aortic regurgitation in left ventricular assist device patients: Does aortic root dilatation contribute to valve incompetence?"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-2458","authenticated-orcid":false,"given":"Gloria","family":"F\u00e4rber","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Saarland University Medical Center  Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6959-1246","authenticated-orcid":false,"given":"Ulrich","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Saarland University Medical Center  Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-6087","authenticated-orcid":false,"given":"Stephanie","family":"Gr\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Jena, Friedrich Schiller University  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Elayan","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Jena, Friedrich Schiller University  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Schwan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Saarland University Medical Center  Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Tkebuchava","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Saarland University Medical Center  Homburg\/Saar Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristo","family":"Kirov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital Jena, Friedrich Schiller University  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulio","family":"Caldonazo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital Jena, Friedrich Schiller University  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Herz\u2010 und Kreislaufzentrum  Rotenburg an der Fulda Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Doenst","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital Jena, Friedrich Schiller University  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.07.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31824708a8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.07.008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCHF.2018.07.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.01.114"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006252"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105223(95)70396\u20109"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz098"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.12.030"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.04.164"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000042"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.08.049"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001674"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101313"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1989"}],"container-title":["Artificial 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