{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:47:29Z","timestamp":1775756849481,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Unfractionated heparin is used as the most common anticoagulation for venovenous extracorporeal membrane oxygenation (VV ECMO) patients. However, it is accompanied by frequent bleeding and thrombotic complications. The aim of the study was to demonstrate the feasibility of Enoxaparin anticoagulation for VV ECMO patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a retrospective analysis of VV ECMO patients on continuous intravenous Enoxaparin anticoagulation. The primary outcome was the incidence of bleeding, thrombotic, and neurological complications during ECMO support. The secondary outcome was an analysis of secondary and primary hemostasis profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 38 patients were analyzed in this study. The incidence of bleeding complications was 5.3%, for thrombotic complications it was 2.6% and for neurological (bleeding\/ischemic events) complications it was 10.5%. The targeted anti\u2010Xa activity of 0.4\u20130.6\u2009IU\/mL was achieved and maintained during whole ECMO period in 28 patients (73.8%), not affecting the hemocoagulation profile represented by APTT\u2010r 1.15\u2009\u00b1\u20090.2, TT 18.67\u2009\u00b1\u20093.35\u2009s, PT\/INR 1.21\u2009\u00b1\u20090.19, fibrinogen 5.39\u2009\u00b1\u20091.49\u2009g\/L, antithrombin, and platelet count. Primary hemostasis pathology was diagnosed in all patients by PFA 200 tests Col\/EPI 279\u2009\u00b1\u200938\u2009s and Col\/ADP 249\u2009\u00b1\u200966\u2009s. The running time of ECMO was 7.8\u2009\u00b1\u20093.4\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Enoxaparin anticoagulation appears to be feasible for VV ECMO patients without an increase in adverse events. Further larger\u2010sampled and comparative studies are needed in the future to support our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14879","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T13:01:49Z","timestamp":1727960509000},"page":"486-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous enoxaparin guided by anti\u2010Xa in venovenous extracorporeal membrane oxygenation: A retrospective, single\u2010center study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-8235","authenticated-orcid":false,"given":"Miroslav","family":"Durila","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Second Faculty of Medicine, Charles University and Motol University Hospital  Prague Czech 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