{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:13:18Z","timestamp":1766754798184,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aortic regurgitation (AR) is a well\u2010known cause of impaired outcome in patients with centrifugal left ventricular assist devices (cfLVADs). The failure of the aortic valve (AV) to open at least intermittently is associated with cusp remodeling, commissural fusion, and ultimately developing AR.<\/jats:p><jats:p>Our aim was to characterize patients in whom AV opening (AVO) was preserved 6\u2009months after implantation and identify determinants related to it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We conducted standardized echocardiography and collected clinical and laboratory tests at the outpatient clinic 6\u2009months after implantation. We classified patients into those showing intermittently opening of the AV, every 2\u20133 beats, or in every cycle (AVO) and those whose AV was continuously closed (NAVO). From the 219 cfLVAD implanted in our center between March 2018 and January 2020, 156 subjects were alive and on the device after 6\u2009months. In 2 of the reviewed echocardiograms, we could not evaluate the AV. 99 patients (64%) showed AVO compared to 55 (36%) with NAVO. The first presented higher mean arterial pressure (84\u2009\u00b1\u200910 vs. 77\u2009\u00b1\u200913\u2009mm\u2009Hg, <jats:italic>p =<\/jats:italic> 0.002), larger LV end\u2010diastolic diameter (LVEDD 57.5\u2009\u00b1\u200912 vs. 52.7\u2009\u00b1\u200913\u2009mm, <jats:italic>p =<\/jats:italic> 0.022), a better TAPSE (15\u2009\u00b1\u20094 vs. 13\u2009\u00b1\u20094\u2009mm, <jats:italic>p<\/jats:italic> = 0.028), and less frequently significant AR than patients with NAVO (moderate\/severe AR in 6% vs. in 20%, <jats:italic>p<\/jats:italic> = 0.042). In a multiple logistic regression, a lower NYHA Class, a larger LVEDD, and a better LV ejection fraction appeared as significant predictors of AVO. After a median follow\u2010up of 3.2\u2009years, we found no significant impact on survival stratifying patients by AVO (log\u2010rank <jats:italic>p<\/jats:italic> = 0.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AVO was associated with better RV function, lower NYHA Class, and a lower rate of significant AR. This could indicate that AVO should be pursued in LVAD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14891","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T10:59:13Z","timestamp":1729853953000},"page":"441-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Potential benefits of aortic valve opening in patients with left ventricular assist devices"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-4467","authenticated-orcid":false,"given":"Elena","family":"Romero Dorta","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Meyn","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"Department of Internal Medicine and Cardiology Sana Paulinenkrankenhaus Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-1668","authenticated-orcid":false,"given":"Markus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-5830","authenticated-orcid":false,"given":"Christoph","family":"Hoermandinger","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-1295","authenticated-orcid":false,"given":"Felix","family":"Schoenrath","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-8620","authenticated-orcid":false,"given":"Volkmar","family":"Falk","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"Department of Health Sciences and Technology, Translational Cardiovascular Technology Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-2478","authenticated-orcid":false,"given":"Alexander","family":"Meyer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-9744","authenticated-orcid":false,"given":"Nicolas","family":"Merke","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-3175","authenticated-orcid":false,"given":"Evgenij","family":"Potapov","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-263X","authenticated-orcid":false,"given":"Johanna","family":"Mulzer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-0016","authenticated-orcid":false,"given":"Jan","family":"Knierim","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin und Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"Department of Internal Medicine and Cardiology Sana Paulinenkrankenhaus Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.07.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15338"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010232"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.01.114"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006067"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046415"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.12.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.05.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318160"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.03.033"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14759"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13693"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.06.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032617"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.11.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.01.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.11.008"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T08:22:47Z","timestamp":1740903767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/aor.14891"],"URL":"https:\/\/doi.org\/10.1111\/aor.14891","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"type":"print","value":"0160-564X"},{"type":"electronic","value":"1525-1594"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"assertion":[{"value":"2024-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}