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Currently, renal replacement therapy (RRT) serves as the standard of care for hyperkalemic patients who fail to respond to medical management. However, RRT is difficult to administer in combat settings, and the time between evacuation and RRT is critical in preventing post\u2010traumatic hyperkalemia. Therefore, the need for portable, easily operable hemofiltration technology is pressing to improve the survival of hyperkalemic patients in austere settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this manuscript, we present extra\u2010corporeal direct contact and hemodialysis filtration systems for treating severe hyperkalemia and tested the efficacy, biocompatibility, and performance of a zeolite\u2010based renal RRT. We tested the uptake capacity of an adsorbent zeolite optimized for the selective binding and removal of potassium in various mediums, including dialysate, bovine serum, and whole bovine sodium heparinized blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>Our results show that we can restore physiological normokalemic levels within just 2 h of testing and maintain these levels for 6 h. Furthermore, calcium and sodium levels were maintained within normal physiological ranges, confirming the selectivity of our sorbent material for potassium binding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14919","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T02:49:12Z","timestamp":1734144552000},"page":"670-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hemofiltration system for the post traumatic treatment of hyperkalemia in austere conditions"],"prefix":"10.1111","volume":"49","author":[{"given":"Meredith","family":"Haanstad","sequence":"first","affiliation":[{"name":"TDA Research, Inc.  Wheat Ridge Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie D.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine, School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Biomedical Engineering, School of Engineering University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Srinivas","sequence":"additional","affiliation":[{"name":"TDA Research, Inc.  Wheat Ridge Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Chamot","sequence":"additional","affiliation":[{"name":"TDA Research, Inc.  Wheat Ridge Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Haanstad","sequence":"additional","affiliation":[{"name":"TDA Research, Inc.  Wheat Ridge Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Marotta","sequence":"additional","affiliation":[{"name":"TDA Research, Inc.  Wheat Ridge Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-2037","authenticated-orcid":false,"given":"Palaniappan","family":"Sethu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine, School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Department of Biomedical Engineering, School of Engineering University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2909-5264","authenticated-orcid":false,"given":"Ambalavanan","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"TDA Research, Inc.  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