{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:40:38Z","timestamp":1792194038506,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Left ventricular assist device (LVAD) therapy may lead to an aortic regurgitation, limiting left ventricular unloading and causing adverse events. Whether concomitant aortic valve replacement may improve outcomes in patients with preoperative mild\u2010to\u2010moderate aortic regurgitation remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective propensity score\u2010matched analysis of adult patients with preoperative mild\u2010to\u2010moderate aortic regurgitation undergoing durable LVAD implantation between 01\/01\/2011 and 30\/11\/2021 was performed. Patients undergoing concomitant valve surgery other than biological aortic valve replacement were excluded, resulting in 77 with concomitant biological aortic valve replacement and 385 without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following 1:1 propensity score matching, two groups of 55 patients with and without biological aortic valve replacement were obtained, (mean age 59\u2009\u00b1\u200911\u2009years, 92% male, 59.1% HeartWare). Aortic regurgitation was mild in 72.7% and 76.4% and moderate in 27.3% and 23.6% in non\u2010replacement and replacement cohorts respectively. The 30\u2010day survival was 89.1% vs. 85.5% (<jats:italic>p<\/jats:italic>\u2009=\u20090.59), 1\u2010year survival 69.1% vs. 56.4% (<jats:italic>p<\/jats:italic>\u2009=\u20090.19), and 2\u2010year survival 61.8% vs. 47.3% (<jats:italic>p<\/jats:italic>\u2009=\u20090.10) in the non\u2010replacement and replacement groups, respectively. After a mean follow\u2010up of 1.2\u2009years, non\u2010replacement patients had a higher incidence of pump thrombosis (11 [20%] vs. 3 [5.5%], <jats:italic>p<\/jats:italic>\u2009=\u20090.022) and fewer major bleedings (2 [3.6%] vs. 11 [20%], <jats:italic>p<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with those treated conservatively, patients with mild\u2010to\u2010moderate aortic regurgitation undergoing concomitant aortic valve replacement during LVAD implantation have a similar survival up to 2\u2009years on support. Patients with concomitant valve replacement had a higher risk of bleeding complications but fewer pump thromboses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14926","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T06:38:59Z","timestamp":1733812739000},"page":"691-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of concomitant aortic valve replacement in patients with mild\u2010to\u2010moderate aortic valve regurgitation undergoing left ventricular assist device implantation: EUROMACS analysis"],"prefix":"10.1111","volume":"49","author":[{"given":"Gregorio","family":"Gliozzi","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, Cardiothoracic Department University Hospital of Udine  Udine Italy"},{"name":"Department of Medical and Surgical Sciences (DIMES) Alma Mater Studiorum \u2013 University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-7705","authenticated-orcid":false,"given":"Gaik","family":"Nersesian","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"additional","affiliation":[{"name":"City of Health and Science Hospital Turin, Department of Surgical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Schoenrath","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Netuka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Institute for Clinical and Experimental Medicine  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-3348","authenticated-orcid":false,"given":"Theo M. 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H.","family":"de By","sequence":"additional","affiliation":[{"name":"EUROMACS Registry EACTS  Windsor UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-2458","authenticated-orcid":false,"given":"Gloria","family":"Faerber","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Jena University Hospital, Friedrich Schiller University  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4410-6232","authenticated-orcid":false,"given":"Antonio","family":"Spitaleri","sequence":"additional","affiliation":[{"name":"City of Health and Science Hospital Turin, Department of Surgical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Vendramin","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Cardiothoracic Department University Hospital of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gummert","sequence":"additional","affiliation":[{"name":"Department of Thoracic, Cardiac and Vascular Surgery Heart and Diabetes Centre  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkmar","family":"Falk","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiovascular Surgery Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Health Sciences and Technology ETH Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Leuven  Leuven 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