{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:28:14Z","timestamp":1760236094392,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In cell\u2010free and concentrated ascites reinfusion therapy (CART), filtration membrane obstruction during the ascites processing step is an important clinical problem. A novel membrane designed polyether sulfone filter (n\u2010PES) was developed to reduce filter membrane obstruction. However, no clinical studies have compared the performance of n\u2010PES filters with that of conventional filters. Therefore, we aimed to assess whether n\u2010PES filters reduce membrane obstruction compared to conventional polyethylene (PE) filters during CART ascites processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, retrospective, observational, controlled cohort study. We compared ascites processing records from the drop\u2010type with adjustable concentrator CART (DC\u2010CART) sessions that used n\u2010PES filters with those that used conventional PE filters. The primary outcome was the occurrence rate of membrane obstruction. Propensity score matching was used to assemble DC\u2010CART sessions with comparable baseline ascites characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 173\u2009DC\u2010CART sessions, 31 sessions using n\u2010PES filters and 31 using PE filters with similar propensity scores were included in the analysis. The rate of filter membrane obstruction was significantly lower in the n\u2010PES group than in the PE group (<jats:italic>p<\/jats:italic>\u2009=\u20090.049). Additionally, the total treatment time was significantly shorter for the n\u2010PES group (<jats:italic>p<\/jats:italic>\u2009=\u20090.006). No sessions experienced issues with the processing procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to demonstrate that an n\u2010PES filter reduces the incidence of filter membrane obstruction in clinical CART sessions using human ascites. The n\u2010PES filter may reduce the burden on the medical staff performing CART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14932","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T07:44:04Z","timestamp":1734939844000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Membrane Designed Polyether Sulfone Filter Reduces Filtration Membrane Obstruction Rate in Drop\u2010Type With Adjustable Concentrator Cell\u2010Free and Concentrated Ascites Reinfusion Therapy (<scp>DC<\/scp>\u2010<scp>CART<\/scp>)"],"prefix":"10.1111","volume":"49","author":[{"given":"Keita","family":"Inui","sequence":"first","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-8426","authenticated-orcid":false,"given":"Daiki","family":"Aomura","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology 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