{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:48:29Z","timestamp":1782316109168,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Normothermic machine perfusion (NMP) is increasingly used to preserve and assess donor livers prior to transplantation. Due to its success, it is expected that more centers will start using this technology. However, NMP may also cause adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective, observational study, we investigated the effect of NMP pressures on donor liver weight, post\u2010transplant outcomes, and hepatic perfusion characteristics. A total of 36 livers were transplanted after NMP. NMP perfusion pressure settings were lowered from a median (IQR) of 47\u2009mmHg (42\u201354) to 34\u2009mmHg (30\u201339) for the hepatic artery (HA), and from 8\u2009mmHg (7\u201310) to 7\u2009mmHg (6\u20138) for the portal vein (PV) to diminish potential edema formation inside the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This change appeared to lead to a reduction of liver weight after NMP (\u221222\u2009g to \u2212143\u2009g, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), without affecting the PV flow velocity (35.5 to 48.0\u2009cm\/s, <jats:italic>p<\/jats:italic>\u2009=\u20090.54), or hepatocellular injury markers during NMP (AST 1511\u20131148\u2009U\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.44; ALT 318\u2013849\u2009U\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.35), and post\u2010transplantation outcomes. Changes in liver weight correlated significantly with the applied PV pressure during NMP (<jats:italic>r<\/jats:italic>\u2009=\u20090.52, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and the HA flow (<jats:italic>r<\/jats:italic>\u2009=\u20090.38, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NMP can lead to a reduction in liver weight, which might be masked by edema when high perfusion pressures are used. We encourage applying the lowest perfusion pressures possible to reach adequate flows and oxygen supply during liver NMP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14939","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T13:09:59Z","timestamp":1735650599000},"page":"820-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-1112","authenticated-orcid":false,"given":"Bianca","family":"Lascaris","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-4901","authenticated-orcid":false,"given":"Silke B.","family":"Bodewes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-2364","authenticated-orcid":false,"given":"Adam M.","family":"Thorne","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-7107","authenticated-orcid":false,"given":"Marius C.","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-6781","authenticated-orcid":false,"given":"Robbert J.","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-9392","authenticated-orcid":false,"given":"Maarten W. N.","family":"Nijsten","sequence":"additional","affiliation":[{"name":"Department of Critical Care University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-5917","authenticated-orcid":false,"given":"Vincent E.","family":"de Meijer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-734X","authenticated-orcid":false,"given":"Robert J.","family":"Porte","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Erasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002127"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01242.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0047-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017733"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003462"},{"key":"e_1_2_8_9_1","volume-title":"Capillary Fluid Exchange: Regulation, Functions, and Pathology","author":"Scallan J.","year":"2010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617742832"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2011.09.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15228"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010235"},{"issue":"8","key":"e_1_2_8_14_1","first-page":"897","article-title":"Colloid Osmotic Pressure: Its Measurement and Clinical Value","volume":"116","author":"Morissette M. 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