{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:34:21Z","timestamp":1762342461264,"version":"3.40.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplantation (KT) is the most effective treatment for end\u2010stage renal disease. End\u2010ischemic hypothermic machine perfusion (EI\u2010HMP) has emerged as a promising method for preserving grafts before transplantation. This study aimed to compare graft function recovery in KT recipients of deceased brain\u2010death (DBD) grafts preserved with EI\u2010HMP versus static cold storage (SCS). The primary outcome was the rate of delayed graft function (DGF). Secondary outcomes included urine output, intensive care unit (ICU) stay, hospital stay duration, and survival rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, single\u2010center observational study was conducted at Sapienza University of Rome, analyzing 313 KT patients between January 2014 and September 2021. Patients were stratified into two groups based on graft preservation methods (EI\u2010HMP, <jats:italic>n<\/jats:italic>\u2009=\u200995; SCS, <jats:italic>n<\/jats:italic>\u2009=\u2009218). A stabilized inverse probability treatment weighting (IPTW) method was employed to adjust for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in DGF rates between the two groups (17.9% vs. 15.6% in SCS and EI\u2010HMP cases, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.75). EI\u2010HMP group demonstrated a higher urine output on day 2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.046), a shorter ICU stay (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and a trend toward a shorter overall hospital stay (<jats:italic>p<\/jats:italic>\u2009=\u20090.07). No statistically significant differences were found between EI\u2010HMP and SCS cases in 1\u2010 and 3\u2010year overall survival rates (3.2% and 6.7% vs. 5.6% and 6.6%, respectively; log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.53) or in death\u2010censored graft loss rates (5.4% and 8.9% vs. 5.7% and 7.3%, respectively; log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.88). In a sub\u2010analysis of expanded criteria donors (ECD), EI\u2010HMP demonstrated a protective effect by reducing the risk of DGF (OR\u2009=\u20090.31, 95% CI\u2009=\u20090.09\u20130.95; <jats:italic>p<\/jats:italic>\u2009=\u20090.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EI\u2010HMP was associated with certain short\u2010term benefits, including increased urine output and reduced ICU stays, but showed no significant impact on long\u2010term survival outcomes. A reduction in DGF rates was observed only in the ECD subgroup. Randomized controlled trials are necessary to further investigate the long\u2010term clinical benefits of EI\u2010HMP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14953","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T07:28:13Z","timestamp":1737790093000},"page":"831-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short (2\u2010Hour) Non\u2010Oxygenated End\u2010Ischemic Hypothermic Perfusion Versus Cold Storage in the Setting of Renal Transplantation"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7282-9457","authenticated-orcid":false,"given":"Franco","family":"Ruberto","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Critical Care Medicine and Pain Therapy Sapienza University of Rome  Rome 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Diamantini","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Brisciani","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care Medicine and Pain Therapy Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Giovanardi","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Melandro","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Quaresima","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Rossi","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Garofalo","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care Medicine and Pain Therapy Sapienza University of Rome  Rome 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