{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:05:51Z","timestamp":1791864351334,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients on maintenance hemodialysis (HD) face complications due to the accumulation of protein\u2010bound uremic toxins, such as advanced glycation end products (AGEs), which contribute to inflammation, oxidative stress, and cardiovascular disease. Conventional HD techniques inadequately remove AGEs. This study evaluates the efficacy of the HA130 hemoadsorption cartridge combined with high\u2010flux HD (HF\u2010HD) in enhancing AGE removal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, single\u2010center study included 20 maintenance HD patients randomized into two groups: HF\u2010HD alone (<jats:italic>n<\/jats:italic>\u2009=\u200910) and HF\u2010HD plus hemoadsorption (<jats:italic>n<\/jats:italic>\u2009=\u200910). Blood samples were collected before and after a single session to measure carboxymethyllysine (CML), soluble RAGE (sRAGE), prolactin, and parathyroid hormone (PTH) levels. Reduction ratios (RR) were calculated, including corrected for hemoconcentration (RRc), to ensure accuracy. Statistical analyses included Mann\u2013Whitney <jats:italic>U<\/jats:italic> and Chi\u2010square tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HF\u2010HD plus hemoadsorption group showed significantly enhanced removal of CML compared to HF\u2010HD alone, with RRc of 64.7% [52.6\u201374.9] versus 39.3% [33.8\u201349.4], respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.045). Similarly, uncorrected reduction ratios demonstrated a trend favoring hemoadsorption, with values of 57.5% [45.1\u201370.7] versus 30.3% [19.1\u201344.5] (<jats:italic>p<\/jats:italic>\u2009=\u20090.053). Importantly, sRAGE levels were preserved in both groups (RRc: 23.4% (15.1\u201330.4) vs. 21.8% (16.6\u201331.7), <jats:italic>p<\/jats:italic>\u2009=\u20090.791), highlighting the safety of hemoadsorption. Other biochemical parameters, including prolactin, PTH, albumin, and electrolytes, showed no significant differences between groups. All sessions were completed without adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combining hemoadsorption with HF\u2010HD significantly enhances CML removal, as evidenced by corrected RR, without compromising protective sRAGE levels. This innovative approach offers a promising adjunctive therapy for reducing AGEs\u2010related complications in end\u2010stage renal disease patients. Further longitudinal studies are needed to confirm these findings and evaluate long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14954","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:57:48Z","timestamp":1737460668000},"page":"900-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of <scp>HA130<\/scp> Hemoadsorption in Removing Advanced Glycation End Products in Maintenance Hemodialysis Patients"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-9997","authenticated-orcid":false,"given":"Gonzalo","family":"Ram\u00edrez\u2010Guerrero","sequence":"first","affiliation":[{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"},{"name":"International Renal Research Institute of Vicenza  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-117X","authenticated-orcid":false,"given":"Thiago","family":"Reis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Faculty of Health Sciences University of Bras\u00edlia  Bras\u00edlia Brazil"},{"name":"Division of Nephrology University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"},{"name":"CPQuali Pesquisa Cl\u00ednica Clinical Research Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Segovia\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Aranda","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Verdugo","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Pedreros\u2010Rosales","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina Universidad de Concepci\u00f3n  Concepci\u00f3n Chile"},{"name":"Nephrology Service Hospital Las Higueras  Talcahuano Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Marcello","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza  Vicenza Italy"},{"name":"Department of Nephrology, Dialysis and Transplantation St. Bortolo Hospital Vicenza  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit Carlos Van Buren Hospital  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Rojas","sequence":"additional","affiliation":[{"name":"Biomedical Research Laboratories, Faculty of Medicine Catholic University of Maule  Talca Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza  Vicenza Italy"},{"name":"Department of Nephrology, Dialysis and Transplantation St. Bortolo Hospital Vicenza  Vicenza Italy"},{"name":"Department of Medicine (DIMED) Universit\u00e0 Degli Studi di Padova  Padova 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