{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T14:01:09Z","timestamp":1780149669310,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left ventricular assist device (LVAD) implantation can be used to manage advanced heart failure. Debates over sex differences in postoperative outcomes of LVAD implantation remain contentious; there is limited evidence available from the continuous\u2010flow era, particularly following the introduction of third\u2010generation devices. This study aimed to conduct a comprehensive, contemporary, and population\u2010based analysis of the sex difference in the in\u2010hospital outcomes following LVAD implantations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent LVAD implantation were selected from National Inpatient Sample from Q4 2015\u20132021. Multivariable logistic regression was used to compare in\u2010hospital outcomes between females and males, where demographics, socioeconomic status, primary payer status, hospital characteristics, comorbidities, and transfer\/admission status were adjusted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 1201 (23.6%) female and 3881 (76.4%) male patients who underwent LVAD implantation. Females and males had comparable in\u2010hospital mortality, MACE, and stroke. However, females had higher diaphragmatic paralysis (aOR\u2009=\u20097.94, 95 CI\u2009=\u20091.46\u201343.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Meanwhile, females had lower cardiogenic shock (aOR\u2009=\u20090.85, 95 CI\u2009=\u20090.73\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), renal complications (aOR\u2009=\u20090.72, 95 CI\u2009=\u20090.62\u20130.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and infection (aOR\u2009=\u20090.70, 95 CI\u2009=\u20090.58\u20130.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Females also had longer hospital length of stay (44.1\u2009\u00b1\u200940.0 vs. 38.8\u2009\u00b1\u200930.6\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and higher total hospital charges (1293779.0\u2009\u00b1\u20091182139.0 vs. 1172780.0\u2009\u00b1\u2009917544.0 US dollars,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the contemporary era with the introduction of third\u2010generation devices, in\u2010hospital mortality and stroke after LVAD implantation continued to decrease and were comparable in both sexes. However, there are still notable sex\u2010based differences in the complications of LVAD implantation, which underscores the need for sex\u2010specific preoperative risk assessments and tailored perioperative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14965","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T05:03:51Z","timestamp":1738559031000},"page":"1053-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in the In\u2010Hospital Outcomes of Left Ventricular Assist Device Implantation: A Population\u2010Based National Inpatient Sample Study From 2015 to 2021"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-6278","authenticated-orcid":false,"given":"Renxi","family":"Li","sequence":"first","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyanira J.","family":"Prastein","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery The George Washington University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Boyce","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery The George Washington University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"issue":"128","key":"e_1_2_11_3_1","first-page":"e240","article-title":"ACCF\/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"2013","author":"WRITING COMMITTEE MEMBERS","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.04.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2003.24"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.063"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027251"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.10.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067758"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz098"},{"key":"e_1_2_11_13_1","first-page":"770","article-title":"Sex Differences in Patients Receiving Left Ventricular Assist Devices for End\u2010Stage Heart Failure","volume":"8","author":"Gruen J.","year":"2020","journal-title":"Journal of the American College of Cardiology: Heart Failure"},{"key":"e_1_2_11_14_1","article-title":"Sex\u2010Based Differences in Left Ventricular Assist Device Utilization. Circulation","volume":"12","author":"Joshi A. A.","year":"2019","journal-title":"Heart Failure"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14261"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30892"},{"key":"e_1_2_11_17_1","first-page":"250","article-title":"Sex\u2010Related Differences in Use and Outcomes of Left Ventricular Assist Devices as Bridge to Transplantation","volume":"7","author":"DeFilippis E. 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