{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:29:43Z","timestamp":1786512583003,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prior studies of anticoagulation bridging during periods of low International Normalized Ratio (INR) in outpatients with a durable, continuous flow left ventricular assist device (CF\u2010LVAD) have shown a variable impact on thrombotic and bleeding events. These studies include predominantly older devices such as the HeartMate 2 (HM2) and HeartWare HVAD, which are known to experience more overall thrombotic events than the HeartMate 3 (HM3) device. The majority of these patients also received concomitant aspirin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The primary objective of this study was to compare hemocompatibility\u2010related adverse events (HRAEs) occurring while bridging subtherapeutic (\u2264\u20091.7) INRs with therapeutic low\u2010molecular weight heparin (LMWH) versus not bridging in outpatients with an HM3 CF\u2010LVAD, many of whom were not receiving concomitant aspirin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 79 patients eligible for inclusion in this study, 64 were not bridged and 15 were bridged at least once during the study period. In the non\u2010bridged group, there were a total of 12 HRAEs of 997 bridging opportunities (BOs) (1.20%) versus 0 of 39 BOs in the bridged group. Of the 12 HRAEs in the non\u2010bridged group, 10 were bleeding events; the 2 thrombotic events were minor venous thromboembolisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Omission of LMWH bridging in HM3 CF\u2010LVAD patients with a subtherapeutic INR and low rates of background aspirin use did not result in a statistically significant or clinically relevant increase in the rate of HRAEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14986","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:46:09Z","timestamp":1741736769000},"page":"1215-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemocompatibility\u2010Related Adverse Events Associated With or Without Low Molecular Weight Heparin Bridging in Outpatients With a\n                    <scp>HeartMate<\/scp>\n                    3 Left Ventricular Assist Device"],"prefix":"10.1111","volume":"49","author":[{"given":"Julia R.","family":"James","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of North Carolina Hospitals  Chapel Hill North Carolina USA"},{"name":"Department of Pharmacy WakeMed Health &amp; Hospitals  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Hospitals  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison Hanford","family":"Hunt","sequence":"additional","affiliation":[{"name":"University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"},{"name":"Department of Pharmacy Novant Health Presbyterian Medical Center  Huntersville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Hospitals  Chapel Hill North Carolina USA"},{"name":"University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quefeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Gillings School of Global Public Health  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-9663","authenticated-orcid":false,"given":"Arwa","family":"Omary","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Hospitals  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-3706","authenticated-orcid":false,"given":"Ian B.","family":"Hollis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Hospitals  Chapel Hill North Carolina USA"},{"name":"University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.12.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000449"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000592"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000612"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001392"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14684"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002067"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2211"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14652"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.23204"},{"key":"e_1_2_7_12_1","unstructured":"Kirklin Solutions \u2010 STS Intermacs \u201cINTERMACS Appendices; Appendix A \u2013 Adverse Event Definitions. Version 10\/11\/21 \u201daccessed June 28 2024 https:\/\/intermacs.kirso.net\/intermacs\u2010documents\/."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025993"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20108703(03)00121\u20102"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000002454"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:58:54Z","timestamp":1786510734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/aor.14986"],"URL":"https:\/\/doi.org\/10.1111\/aor.14986","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"2024-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}