{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:29:42Z","timestamp":1786512582507,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite major advancements in the field of durable left ventricular assist devices (LVADs), driveline infection is a major source of morbidity and mortality. Risk factors have been proposed, but few are modifiable. We evaluated vitamin D deficiency as a potential modifiable risk factor for driveline infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      This single\u2010center, retrospective study included 134 LVAD recipients between 2010 and 2022. Patients were divided into two groups based on their pre\u2010implant vitamin D levels: the vitamin D sufficient group (\u2265\u200930\u2009ng\/mL) and the vitamin D deficient group (&lt;\u200930\u2009ng\/mL). The Kaplan\u2013Meier method estimated 18\u2010month freedom from driveline infection. The Cox proportional hazards model estimated the effect of vitamin D deficiency on driveline infections. Kaplan\u2013Meier estimates for infection\u2010free survival were significantly higher in the sufficient group (90.5% vs. 69.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). Vitamin D deficiency (HR: 3.644, 95% CI: 1.271\u201310.448,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and obesity (HR: 3.190, 95% CI: 1.464\u20137.400,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) were found to be independent risk factors for driveline infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support vitamin D deficiency as a potential modifiable risk factor for driveline infection. Obesity was also noted as a significant risk factor for infection. Further research is warranted to establish causality and assess the impact of vitamin D repletion on infection rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14988","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T05:54:27Z","timestamp":1742190867000},"page":"1185-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D Deficiency and Driveline Infections in Patients With Left Ventricular Assist Devices"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-8085","authenticated-orcid":false,"given":"Wesley A.","family":"Borman","sequence":"first","affiliation":[{"name":"Department of Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke M.","family":"Landrigan","sequence":"additional","affiliation":[{"name":"Department of Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5270-7321","authenticated-orcid":false,"given":"Nicholas J.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Pickrell","sequence":"additional","affiliation":[{"name":"Indiana University Health, Methodist Hospital  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya E.","family":"Guglin","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0b013e318291329a"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"issue":"10","key":"e_1_2_8_4_1","first-page":"722","article-title":"Advanced Heart Failure Epidemiology and Outcomes: A Population\u2010Based Study","volume":"9","author":"Dunlay S. 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