{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:50:38Z","timestamp":1791600638383,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glutaraldehyde (GA) generates cross\u2010links between cardiovascular xenografts to obtain tissue stability and attenuate antigenicity. However, the long\u2010term durability of GA\u2010fixed cardiovascular xenografts treated with previous anticalcification strategies has remained a challenge because tissue phospholipids, free aldehyde groups of GA, and residual antigenicity contribute to calcification. This study aimed to assess the safety, efficacy, and clinical performance of a bovine pericardial scaffold treated with our novel anticalcification protocols (Periborn) in patients with cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bovine pericardia were decellularized with 0.25% sodium dodecyl sulfate, 0.5% Triton X\u2010100, and treated with a space\u2010filler with polyethylene glycol. These tissues were cross\u2010linked with 0.5% GA in a 75% ethanol +5% octanol organic solvent and treated with glycine for detoxification to produce Periborn. Between July 2015 and April 2022, 451 Periborn patches were implanted in 352 cases for cardiovascular surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age at the time of surgery was 22.74\u2009\u00b1\u200920.09\u2009years (13\u2009days\u201389.5\u2009years), follow\u2010up duration was 4.25\u2009\u00b1\u20092.56\u2009years (17\u2009days\u20138.6\u2009years), and no patch\u2010related mortalities were observed. Five patients were reoperated owing to patch\u2010related complications including decreased mobility, erosion, pseudoaneurysm, and calcification, and the overall probability of freedom from Periborn\u2010related reoperation was 99.4%\u2009\u00b1\u20090.4% at 1\u2009year, 98.6%\u2009\u00b1\u20090.7% at 5\u2009years, and 95.4%\u2009\u00b1\u20093.2% at 9\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This retrospective study demonstrates the safety and efficacy of the tissue\u2010engineered Periborn bovine pericardial scaffold for the surgical repair of various cardiovascular diseases. The excellent durability and hemodynamic performance of Periborn make our novel anti\u2010calcification protocol attractive and may require long\u2010term follow\u2010up to confirm durability and further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15010","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T06:34:05Z","timestamp":1744353245000},"page":"1307-1313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Results for Cardiovascular Xenografts Treated With Novel Anticalcification Protocols"],"prefix":"10.1111","volume":"49","author":[{"given":"Hong\u2010Gook","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Sejong General Hospital  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hong","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Sejong General Hospital  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Re","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Sejong General Hospital  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-8265","authenticated-orcid":false,"given":"Yong Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Thoracic and Cardiovascular Surgery Sejong General Hospital  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.05.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2012.0289"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.259747"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.07.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2013.46.1.1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu385"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjon.2020.06.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2014.47.4.333"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000161"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx131"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.02.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2010.43.1.11"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2012.45.5.287"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26910"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.006494"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29865"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30968"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2012.45.6.380"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2012.45.6.368"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2010.43.6.565"},{"key":"e_1_2_8_22_1","first-page":"550","article-title":"Study on an Effective Decellularization Technique for Cardiac Valve, Arterial Wall and Pericardium Xenographs: Optimization of Decellularization","volume":"41","author":"Park C. 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