{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:39:45Z","timestamp":1761223185215,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The critical importance of effective oxygen delivery during organ preservation to prevent ischemia\u2013reperfusion injury has been reported in the literature. Moreover, traditional preservation methods often fail to meet oxygenation needs, prompting research into alternatives like hemoglobin\u2010based oxygen carriers (HBOCs) such as M101 provided by HEMARINA. This extracellular hemoglobin, derived from\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Arenicola marina<\/jats:italic>\n                      <\/jats:styled-content>\n                      , shows a high affinity for oxygen and delivers it through a physiological gradient under hypoxic conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this context, the mechanical and functional properties of the heart and diaphragm muscles from Wistar rats were evaluated in the presence of M101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The experiments showed that M101\u2010treated hearts maintained higher contraction amplitudes, heart rates, and coronary flow over time compared to controls, indicating improved functional stability. Furthermore, the M101\u2010treated diaphragm exhibited prolonged contraction and relaxation times, with significant improvements in contraction amplitude at higher stimulation frequencies. Finally, the Burke index revealed reduced fatigue in the M101\u2010treated group compared to the controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that M101 significantly enhances the mechanical and functional properties of both tested muscles under experimental conditions. Further research is warranted to unravel these findings and explore clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15014","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T06:44:46Z","timestamp":1746513886000},"page":"1387-1393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating\n                    <scp>M101<\/scp>\n                    's Effect in Improving Cardiac and Diaphragmatic Mechanical and Functional Properties on Wistar Rat"],"prefix":"10.1111","volume":"49","author":[{"given":"Ollivier","family":"Grimault","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Theron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Boete","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-6111","authenticated-orcid":false,"given":"Mathieu","family":"Maalouf","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Qu\u00e9m\u00e9neur","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-6618","authenticated-orcid":false,"given":"Franck","family":"Zal","sequence":"additional","affiliation":[{"name":"Hemarina SA, Aerop\u00f4le Centre  Morlaix France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karelle","family":"L\u00e9on","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1739-3688","authenticated-orcid":false,"given":"Karine","family":"Pichavant\u2010Rafini","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Brest, EA 4324 ORPHY, IBSAM, UFR Sciences et Techniques  Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.83"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2019.1628217"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.08.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2014.07.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.3908"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200500049"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016312802650814"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19070376"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201048719\u2010x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15798"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14141"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12307"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2011.03614.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100119"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005111"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2017.1392315"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.03.027"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1142\/S2972497X24200013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26020842"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2014.08.013"},{"volume-title":"Pathophysiology for the Health Professions\u2014E\u2010Book","year":"2014","author":"Gould B. 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